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Beneficial Effects of Different Flavonoids on Vascular and Renal Function in L-NAME Hypertensive Rats
dc.contributor.author | Paredes, M. Dolores | |
dc.contributor.author | Romecín, Paola | |
dc.contributor.author | Atucha, Noemí M. | |
dc.contributor.author | O'Valle Ravassa, Francisco Javier | |
dc.contributor.author | Castillo, Julián | |
dc.contributor.author | Ortiz, María Clara | |
dc.contributor.author | García-Estañ, Joaquín | |
dc.date.accessioned | 2019-03-07T13:38:15Z | |
dc.date.available | 2019-03-07T13:38:15Z | |
dc.date.issued | 2018-04-13 | |
dc.identifier.citation | Paredes, M. D. [et al.]. Beneficial Effects of Different Flavonoids on Vascular and Renal Function in L-NAME Hypertensive Rats. Nutrients 2018, 10, 484. [http://hdl.handle.net/10481/54900] | es_ES |
dc.identifier.issn | 2072-6643 | |
dc.identifier.uri | http://hdl.handle.net/10481/54900 | |
dc.description.abstract | Background: we have evaluated the antihypertensive effect of several flavonoid extracts in a rat model of arterial hypertension caused by chronic administration (6 weeks) of the nitric oxide synthesis inhibitor, L-NAME. Methods: Sprague Dawley rats received L-NAME alone or L-NAME plus flavonoid-rich vegetal extracts (Lemon, Grapefruit + Bitter Orange, and Cocoa) or purified flavonoids (Apigenin and Diosmin) for 6 weeks. Results: L-NAME treatment resulted in a marked elevation of blood pressure, and treatment with Apigenin, Lemon Extract, and Grapefruit + Bitter Orange extracts significantly reduced the elevated blood pressure of these animals. Apigenin and some of these flavonoids also ameliorated nitric oxide-dependent and -independent aortic vasodilation and elevated nitrite urinary excretion. End-organ abnormalities such as cardiac infarcts, hyaline arteriopathy and fibrinoid necrosis in coronary arteries and aorta were improved by these treatments, reducing the end-organ vascular damage. Conclusions: the flavonoids included in this study, specially apigenin, may be used as functional food ingredients with potential therapeutic benefit in arterial hypertension. | es_ES |
dc.description.sponsorship | This report was supported by a grant from the National Spanish R&D Program CENIT of the Spanish Ministry of Science and Technology denominated “Industrial research diets and food with specific features for the elderly”, CEN-20091006; Acronym: SENIFOOD.We have not received funds for covering the costs to publish in open access. We acknowledge the assistance of Justin Davis with the English language. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.rights | Atribución 3.0 España | * |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.subject | Flavonoids | es_ES |
dc.subject | Nitric oxide | es_ES |
dc.subject | Neart | es_ES |
dc.subject | Kidney | es_ES |
dc.subject | Sodium balance | es_ES |
dc.subject | Phenylephrine | es_ES |
dc.subject | Acetylcholine | es_ES |
dc.title | Beneficial Effects of Different Flavonoids on Vascular and Renal Function in L-NAME Hypertensive Rats | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es_ES |