Genome-guided identification of novel head-to-tail cyclized antimicrobial peptides, exemplified by the discovery of pumilarin
Metadatos
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Microbiology society
Materia
Genome-mining Bacteriocin Circular peptide Antimicrobial peptide Annotation
Fecha
2017-09Referencia bibliográfica
van Heel, Auke J.; Montalban-Lopez, Manuel; Oliveau, Quentin; Kuipers, Oscar P. Genome-guided identification of novel head-to-tail cyclized antimicrobial peptides, exemplified by the discovery of pumilarin. Microbial Genomics 2017;3. [http://hdl.handle.net/10481/54657]
Patrocinador
MML was supported by ALW-NWO project SynMod (project number 855.01.162) and the FP7 project Synpeptide. AJvH was supported by NWO-STW programme GenBiotics (project number 10466).Resumen
The need for novel antibiotics in an era where antimicrobial resistance is on the rise, and the number of new approved
antimicrobial drugs reaching the market is declining, is evident. The underused potential of post-translationally modified
peptides for clinical use makes this class of peptides interesting candidates. In this study, we made use of the vast amounts
of available genomic data and screened all publicly available prokaryotic genomes (~3000) to identify 394 novel head-to-tail
cyclized antimicrobial peptides. To verify these in silico results, we isolated and characterized a novel antimicrobial peptide
from Bacillus pumilus that we named pumilarin. Pumilarin was demonstrated to have a circular structure and showed
antimicrobial activity against several indicator strains, including pathogens.