Zn-containing polymer nanogels promote cervical dentin remineralization.
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Toledano Pérez, Manuel; Cabello Malagón, Inmaculada; Osorio Ruiz, María Estrella; Sánchez Aguilera, Fátima; Toledano Osorio, Manuel; Medina Castillo, Antonio Luis; Osorio Ruiz, RaquelEditorial
Springer
Materia
Remineralization Zinc Calcium Nanoparticles Cervical dentin
Date
2018-07-03Referencia bibliográfica
Toledano M, Cabello I, Osorio E, Aguilera FS, Medina-Castillo AL, Toledano-Osorio M, Osorio R. Zn-containing polymer nanogels promote cervical dentin remineralization. Clin Oral Investig. 2018 Jul 3. [Epub ahead of print] [http://hdl.handle.net/10481/52856]
Sponsorship
MINECO/FEDER MAT2014-52036-P. MINECO/FEDER MAT2017-85999-P.Abstract
Objective: Nanogels designing for effective treatment of eroded cervical dentin lesions. Materials
and Methods: Polymethylmetacrylate-based nanoparticles (NPs) were doxycycline (D), calcium
or zinc loaded. They were applied on eroded cervical dentin. Treated surfaces were characterized
morphologically by atomic force and scanning electron microscopy, mechanically probed by a
nanoindenter to test nanohardness and Young modulus, and chemically analyzed by Raman
spectroscopy at 24 h and 7 d of storage. Data were submitted to ANOVA and Student-Newman-
Keuls multiple comparisons tests. Results: Dentin treated with Zn-NPs attained the highest
nanomechanical properties, mineralization and crystallinity among groups. Nanoroughness was
lower in Zn-treated surfaces in comparison to dentin treated with un-doped gels. Dentin treated
with Ca-NPs created the minimal calcification at the surface and showed the lowest Young
modulus at peritubular dentin. Intertubular dentin appeared remineralized. Dentinal tubules were
empty in samples treated with D-NPs, partially occluded in cervical dentin treated with undoped
NPs and Ca-NPs, and mineral covered when specimens were treated with Zn-NPs. Conclusions:
Zn-loaded NPs permit functional remineralization of eroded cervical dentin. Based on the tested
nanomechanical and chemical properties, Zn-based nanogels are suitable for dentin
remineralization. Clinical Relevance: The ability of zinc-loaded nanogels to promote dentin
mineralization may offer new strategies for regeneration of eroded cervical dentin and effective
treatment of dentin hypersensitivity.