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Apoferritin fibers: a new template for 1D fluorescent hybrid nanostructures

[PDF] Jurado_ApoferritinFibers.pdf (7.120Mb)
Identificadores
URI: http://hdl.handle.net/10481/41026
DOI: 10.1039/C6NR01044J
ISSN: 2040-3372
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Autor
Jurado, Rocío; Castello, Fabio; Bondia, Patricia; Casado, Santiago; Flors, Cristina; Cuesta Martos, Rafael; Domínguez Vera, José Manuel; Orte Gutiérrez, Ángel; Gálvez Rodríguez, Natividad
Editorial
Royal Society of Chemistry
Materia
Nanoparticles
 
Protein Amyloid
 
Glycoproteins
 
β-lactoglobulin
 
Nanostructures
 
Fecha
2016
Referencia bibliográfica
Jurado, R.; et al. Apoferritin fibers: a new template for 1D fluorescent hybrid nanostructures. Nanoscale: online (2016). [http://hdl.handle.net/10481/41026]
Patrocinador
This work was funded by the Junta de Andalucía (Project P11-FQM-8136 and Project P10-FQM-6154), MINECO (Projects CTQ2012-32236, RyC2011-07637, MAT2012-34487, PTA2011- 6702-I, MAT2015-66605-P and CTQ2015-64538) and the Euro- pean Commission (FP7-PEOPLE-2011-CIG no. 303620).
Resumen
Recently, research in the field of protein amyloid fibers has gained great attention due to the use of these materials as nanoscale templates for the construction of functional hybrid materials. The formation of apoferritin amyloid-like protein fibers is demonstrated herein for the first time. The morphology, size and stiffness of these one-dimensional structures are comparable to the fibers formed by β-lactoglobulin, a protein frequently used as a model in the study of amyloid-like fibrillar proteins. Nanometer-sized globular apoferritin is capable of self-assembling to form 1D micrometer-sized structures after being subjected to a heating process. Depending on the experimental conditions, fibers with different morphologies and sizes are obtained. The wire-like protein structure is rich in functional groups and allows chemical functionalization with diverse quantum dots (QD), as well as with different Alexa Fluor (AF) dyes, leading to hybrid fluorescent fibers with variable emission wavelengths, from green to near infrared, depending on the QD and AFs coupled. For fibers containing the pair AF488 and AF647, efficient fluorescence energy transfer from the covalently coupled donor (AF488) to acceptor tags (AF647) takes place. Apoferritin fibers are proposed here as a new promising template for obtaining hybrid functional materials.
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