Different presence of Chlamydia pneumoniae, herpes simplex virus type 1, human herpes virus 6, and Toxoplasma gondii in schizophrenia: meta-analysis and analytical study
Metadatos
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Gutiérrez-Fernández, José; Luna Del Castillo, Juan De Dios; Mañanes-González, Sara; Carrillo-Ávila, José Antonio; Gutiérrez, Blanca; Cervilla, Jorge A.; Sorlozano Puerto, AntonioEditorial
Dove Press
Materia
Meta-analysis Analytical study Chlamydia pneumoniae Herpes simplex virus type 1 Human herpes virus 6 Toxoplasma gondii Schizophrenia
Fecha
2015Referencia bibliográfica
Gutiérrez-Fernández, J.; et al. Different presence of Chlamydia pneumoniae, herpes simplex virus type 1, human herpes virus 6, and Toxoplasma gondii in schizophrenia: meta-analysis and analytical study. Neuropsychiatric Disease and Treatment, 11: 843-852 (2015). [http://hdl.handle.net/10481/35709]
Patrocinador
Part of this work was presented at the Royal Academy of Medicine of Spain.Resumen
In the present study we have performed both a meta-analysis and an analytical study exploring the presence of Chlamydia pneumoniae, herpes simplex virus type 1, human herpes virus 6, and Toxoplasma gondii antibodies in a sample of 143 schizophrenic patients and 143 control subjects. The meta-analysis was performed on papers published up to April 2014. The presence of serum immunoglobulin G and immunoglobulin A was performed by enzyme-linked immunosorbent assay test. The detection of microbial DNA in total peripheral blood was performed by nested polymerase chain reaction. The meta-analysis showed that: 1) C. pneumoniae DNA in blood and brain are more common in schizophrenic patients; 2) there is association with parasitism by T. gondii, despite the existence of publication bias; and 3) herpes viruses were not more common in schizophrenic patients. In our sample only anti-Toxoplasma immunoglobulin G was more prevalent and may be a risk factor related to schizophrenia, with potential value for prevention.