Differentially expressed genes after treatment with hydroxytyrosol in DMBA-induced rat breast tumors
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Granados Principal, Sergio; Ramírez Tortosa, María Carmen; Quiles Morales, José Luis; Ramírez Tortosa, César Luis; Sánchez Rovira, Pedro; Camacho-Corencia, P.Editorial
Universidad de Granada
Materia
Dataset Animals Chordates Mammals Nonhuman vertebrates Rodents Muridae Rattus norvegicus
Date
2009-06-01Abstract
The aim of this study was to compare the gene expression profile changes of DMBA-induced rat breast tumors after treatment with hydroxytyrosol (a natural compound from virgin olive oil). To this end, a cDNA microarray experiment was performed (Affymetrix’s Rat Genome 230 2.0 array). This gene expression study was carried out on the tumor biopsy samples prior to hydroxytyrosol treatment, and compared with matched tumor biopsy samples after completion of the hydroxytyrosol treatment schedule. The result of this study was the identification of several genes related to apoptosis, cell cycle arrest, proliferation, differentiation, survival and transformation-related genes.