Could radiotherapy effectiveness be enhanced by electromagnetic field treatment?
Metadatos
Mostrar el registro completo del ítemAutor
Artacho Cordón, Francisco; Salinas Asensio, María del Mar; Calvente, Irene; Ríos Arrabal, Sandra; León, Josefa; Román-Marinetto, Elisa; Olea Serrano, Nicolás; Núñez, María IsabelEditorial
MDPI
Materia
Electromagnetic fields Cancer ELF magnetic exposure Radiotherapy Genotoxicity
Fecha
2013-07Referencia bibliográfica
Artacho-Cordón, F.; et al. Could radiotherapy effectiveness be enhanced by electromagnetic field treatment?. International Jorunal of Molecular Sciences, 14(7): 14974-14995 (2013). [http://hdl.handle.net/10481/27777]
Patrocinador
This study was supported by the Instituto de Salud Carlos III, Fondo de Investigación Sanitaria (PI08/0728, Fondos FEDER) to M.I. Núñez. F. Artacho-Cordón is supported by the Spanish Ministry of Science and Education (AP2012-2524). A grant from the Fundación Benéfica San Francisco Javier y Santa Cándida, University of Granada, to S. Ríos-Arrabal greatly aided this work. This research was also funded by the San Cecilio University Hospital, Granada.Resumen
One of the main goals in radiobiology research is to enhance radiotherapy effectiveness without provoking any increase in toxicity. In this context, it has been proposed that electromagnetic fields (EMFs), known to be modulators of proliferation rate, enhancers of apoptosis and inductors of genotoxicity, might control tumor recruitment and, thus, provide therapeutic benefits. Scientific evidence shows that the effects of ionizing radiation on cellular compartments and functions are strengthened by EMF. Although little is known about the potential role of EMFs in radiotherapy (RT), the radiosensitizing effect of EMFs described in the literature could support their use to improve radiation effectiveness. Thus, we hypothesized that EMF exposure might enhance the ionizing radiation effect on tumor cells, improving the effects of RT. The aim of this paper is to review reports of the effects of EMFs in biological systems and their potential therapeutic benefits in radiotherapy.