Novel bead-based platform for direct detection of unlabelled nucleic acids through Single Nucleobase Labelling

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URI: https://hdl.handle.net/10481/101645
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Autor
Venkateswaran, Seshasailam; Luque-González, Maria Angélica; Tabraue-Chávez, Mavys; Fara, Mario Antonio; López-Longarela, Barbara; Cano-Cortes, Victoria; López-Delgado, Francisco Javier; Sánchez-Martín, Rosario María; Ilyine, Hugh; Bradley, Mark; Pernagallo, Salvatore; Díaz-Mochón, Juan José
Editorial
Elsevier
Fecha
2016
Referencia bibliográfica
Talanta, Volume 161, 2016, Pages 489-496, ISSN 0039-9140
Patrocinador
This research was supported by a Scottish Enterprise SMART Grant number SMART/13/070/13/9259. JJDM thanks Spanish Ministerio de Economía y Competitividad for a Ramon y Cajal Fellowship. This research was also partially supported by: a) Marie Curie Career Integration Grants within the 7th European Community Framework Programme (FP7-PEOPLE-2011-CIG-Project Number 294142) to RMSM; b) Marie Curie Career Integration Grants within the 7th European Community Framework Programme (FP7PEOPLE-2012-CIG-Project Number 322276) to JJDM; c) EASTBIO (the East of Scotland BioScience Doctoral Training Partnership funded by the BBSRC). d) Spanish Ministerio de Economía y Competitividad within a FPI Grant BES-2013- 063020 to ALG. These studies were approved and supported by Luminex Corporation and DestiNA Genomics Ltd.
Resumen
Highlights • Direct detection of native microRNAs via Single Nucleotide Labelling. • Detection of native nucleic acids with single base resolution. • One hour assay for direct detection of miRNA with a LoD of 15 fmole.
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