@misc{10481/90347,
year = {2023},
url = {https://hdl.handle.net/10481/90347},
abstract = {Wound healing is a natural physiological reaction to tissue injury. Hydrogels show attractive advantages in
wound healing not only due to their biodegradability, biocompatibility and permeability but also because provide
an excellent environment for cell migration and proliferation. The main objective of the present study was
the design and characterization of a hydrogel loaded with human mesenchymal stromal cells (hMSCs) for use in
would healing of superficial skin injures. Poloxamer 407® was used as biocompatible biomaterial to embed
hMSCs. The developed hydrogel containing 20 % (w/w) of polymer resulted in the best formulation with respect
to physical, mechanical, morphological and biological properties. Its high swelling capacity confirmed the
hydrogel’s capacity to absorb wounds’ exudate. LIVE/DEAD® assay confirm that hMSCs remained viable for at
least 48 h when loaded into the hydrogels. Adding increasing concentrations of hMSCs-loaded hydrogel to the
epithelium did not affect keratinocytes’ viability and healing capacity and all wound area was closed in less than
one day. Our study opens opportunities to exploit poloxamer hydrogels as cell carriers for the treatment of skin
superficial wound.},
publisher = {Elsevier},
keywords = {Hydrogel},
keywords = {Poloxamer},
keywords = {Human mesenchymal stromal cells},
title = {Development and characterization of a poloxamer hydrogel composed of human mesenchymal stromal cells (hMSCs) for reepithelization of skin injuries},
doi = {10.1016/j.ijpharm.2023.123535},
author = {Galocha-León, Cristina and Antich Acedo, Cristina and Voltes Martínez, Ana and Marchal Corrales, Juan Antonio and Mallandrich, Mireia and Halbaut, L. and Rodríguez Lagunas, M.J. and Souto, Eliana B. and Clares Naveros, Beatriz and Gálvez Martín, P.},
}