@misc{10481/90199,
year = {2020},
month = {12},
url = {https://hdl.handle.net/10481/90199},
abstract = {Objective: To assess the prevalence and risk factors for S. aureus and methicillin-resistant S. aureus (MRSA) nasal colonization in Spanish children.

Methods: Cross-sectional study of patients <14 years from primary care centers all over Spain. Clinical data and nasal aspirates were collected from March to July 2018.

Results: A total of 1876 patients were enrolled. Prevalence of S. aureus and MRSA colonization were 33% (95% CI 30.9-35.1) and 1.44% (95% CI 0.9-2), respectively. Thirty-three percent of the children (633/1876) presented chronic conditions, mainly atopic dermatitis, asthma and/or allergy (524/633). Factors associated with S. aureus colonization were age ≥5 years (OR 1.10, 95% CI 1.07-1.12), male sex (OR 1.43, 95% CI 1.17-1.76), urban setting (OR 1.46, 95% CI 1.08-1.97) and the presence of asthma, atopic dermatitis or allergies (OR 1.25; 95% CI: 1.093-1.43). Rural residence was the only factor associated with MRSA colonization (OR 3.62, 95% CI 1.57-8.36). MRSA was more frequently resistant than methicillin-susceptible S. aureus to ciprofloxacin [41.2% vs 2.6%; p<0.0001], clindamycin [26% vs 16.9%; p=0.39], and mupirocin [14.3% vs 6.7%; p=0.18]. None of the MRSA strains was resistant to tetracycline, fosfomycin, vancomycin or daptomycin.

Conclusions: The main risk factors for S. aureus colonization in Spanish children are being above five years of age, male gender, atopic dermatitis, asthma or allergy, and residence in urban areas. MRSA colonization is low, but higher than in other European countries and is associated with rural settings.},
publisher = {DovePress},
keywords = {MRSA},
keywords = {S. aureus},
keywords = {Child},
title = {Staphylococcus aureus Nasal Colonization in Spanish Children. The COSACO Nationwide Surveillance Study},
doi = {10.2147/IDR.S282880},
author = {Del Rosal, Teresa and Méndez-Echevarría, Ana and Garcia-Vera, César and Escosa-Garcia, Luis and Agud, Martin and Chaves, Fernando and Román, Federico and Gutiérrez Fernández, José and Ruiz de Gopegui, Enrique and Ruiz-Carrascoso, Guillermo and Ruiz-Gallego, Maria Del Carmen and Bernet, Albert and Quevedo, Sara Maria and Fernández-Verdugo, Ana Maria and Díez-Sebastian, Jesús and Calvo, Critina and COSACO Study Group},
}