@misc{10481/79186,
year = {2022},
month = {12},
url = {https://hdl.handle.net/10481/79186},
abstract = {Legumes are a highly nutritious source of plant protein, fiber, minerals and vitamins.
However, they also contain several bioactive compounds with significant potential benefits for human
health. The objectives of this study were to evaluate the antioxidant, antitumor and chemopreventive
activity of functional extracts from legumes using raw and germinated flours of six legume species
of commercial interest. The methodology carried out consisted on the development of protein
hydrolysates, assessment of their antioxidant capacity and in vitro tests on T84, HCT15 and SW480
colorectal cancer (CRC) cell lines. Our results showed a high antitumor activity of protein hydrolysate
from M. sativa. Likewise, when combined with 5-Fluorouracile (5-Fu), there was a synergistic
effect using extract concentrations from 50 to 175  g/mL and 5-Fu concentrations from 1.5 to 5  M.
Similarly, the induction effect on detoxifying enzymes by the extracts of M. sativa, germinated V. faba
Baraca   LVzt1 and V. narbonensis, which produced a higher induction rate than the positive control
sulforaphane (10  M), should be highlighted. Therefore, incorporating these enzymes into the
diet could provide nutritional effects, as well as play an effective role in cancer chemoprevention
and therapy.},
organization = {Spanish Ministry of Science, Innovation and Universities, European Union PTQ-17-09172, RTC-2017-6540-1, RTI2018-100934-BI00
and RTC2019-006870-1},
organization = {Junta de Andalucía P18-TP-1420},
organization = {FEDER},
organization = {AGR145 and CTS-107
(Andalusian Government)},
publisher = {MDPI},
keywords = {Fabaceae},
keywords = {Antioxidant},
keywords = {Chemoprevention},
keywords = {Functional extracts},
keywords = {Colon cancer},
title = {Antioxidant and Chemopreventive Activity of Protein Hydrolysates from Raw and Germinated Flour of Legumes with Commercial Interest in Colorectal Cancer},
doi = {10.3390/antiox11122421},
author = {Fuel, Marco and Mesas Hernández, Cristina and Martínez Martínez, Rosario and Ortiz Quesada, Raúl and Quiñonero Muñoz, Francisco José and Kapravelou, Garyfallia and Lozano Melero, Aída and Perazzoli, Gloria and Prados Salazar, José Carlos and Porres Foulquie, Jesús María and Melguizo Alonso, Consolación},
}