@misc{10481/78401,
year = {2022},
month = {11},
url = {https://hdl.handle.net/10481/78401},
abstract = {Inflammation is the response of the immune system to harmful stimuli such as tissue injury, infection or
toxic chemicals, which has the aim of eliminating irritants or pathogenic microorganisms and enhancing
tissue repair. Uncontrolled long-lasting acute inflammation can gradually progress to chronic, causing a
variety of chronic inflammatory diseases that are usually treated with anti-inflammatory drugs, but most
of them are inadequate to control chronic responses and are also associated with adverse side effects.
Thus, many efforts are being directed to develop alternative and more selective anti-inflammatory therapies
from natural products. One main field of interest is the obtaining of bioactive peptides exhibiting
anti-inflammatory activity from sustainable protein sources like edible insects or agroindustry and fishing
by-products. This work highlighted the structure–activity relationship of anti-inflammatory peptides.
Small peptides with molecular weight under 1 kDa and amino acid chain length between 2 to 20 residues
are generally the most active because of the higher probability to be absorbed in the intestine and penetrate
into cells when compared with the larger size peptides. The presence of hydrophobic (Val, Ile, Pro)
and positively charged (His, Arg, Lys) amino acids is another common occurrence for anti-inflammatory
peptides. Interestingly, a high percentage (77%) of these bioactive peptides can be found in alternative
sustainable protein sources such as Tenebrio molitor or sunflower, apart from its original protein source.
However, not all of these peptides with anti-inflammatory potential in vitro achieve good scores by the
in silico bioactivity predictors studied. Therefore, it is essential to implement current bioinformatics tools,
in order to complement in vitro experiments with prior prediction of potential bioactive peptides.},
organization = {I + D + i project from the Regional Ministry of Economic Transformation, Industry, Knowledge and Universities of Andalusia (Spain)	PY20_00021},
publisher = {Royal Society of Chemistry},
title = {Peptides and protein hydrolysates exhibiting anti-inflammatory activity: sources, structural features and modulation mechanisms},
doi = {10.1039/d2fo02223k},
author = {Rivera Jiménez, Julia and Berraquero García, Carmen and Pérez Gálvez, Antonio Raúl and García Moreno, Pedro Jesús and Espejo Carpio, Francisco Javier and Guadix Escobar, Antonio María and Guadix Escobar, Emilia María},
}