@misc{10481/77088,
year = {2022},
month = {8},
url = {https://hdl.handle.net/10481/77088},
abstract = {Adolescence is a period of intense growth and endocrine changes, and obesity and insulinresistance
processes during this period have lately been rising. Selenium (Se) homeostasis is related
to lipid metabolism depending on the form and dose of Se. This study tests the actions of low-dose
selenite and Se nanoparticles (SeNPs) on white (WAT) and brown adipose tissue (BAT) deposition,
insulin secretion, and GPx1, IRS-1 and FOXO3a expression in the WAT of adolescent rats as regards
oxidative stress, adipocyte length and adipokine secretion. Four groups of male adolescent rats
were treated: control (C), low selenite supplementation (S), low SeNP supplementation (NS) and
moderate SeNP supplementation (NSS). Supplementation was received orally through water intake;
NS and NSS rats received two- and tenfold more Se than C animals, respectively. SeNPs were
obtained by reducing Se tetrachloride in the presence of ascorbic acid. For the first time in vivo,
it was demonstrated that low selenite supplementation contributed to increased adipogenesis via
the insulin signaling pathway and LCN2 modulation, while low SeNP administration prevented
fat depots inWAT via the decrease in insulin signaling and FOXO3a autophagy inWAT, lowering
inflammation. These effects were independent of GPx1 expression or activity in WAT. These findings
provide data for dietary approaches to prevent obesity and/or anorexia during adolescence. These
findings may be relevant to future studies looking at a nutritional approach aimed at pre-venting
obesity and/or anorexia in adolescence.},
organization = {Junta de Andalucia},
organization = {FEDER projects funds	US-1380878},
organization = {Spanish Government	PID2019-109371GB-I00},
organization = {VII Plan Propio de Investigacion y Transferencia-University of Seville 2022	2022/00000332	
2022/00000277},
publisher = {MDPI},
keywords = {Selenite},
keywords = {Nanoparticles},
keywords = {Adipose tissue},
keywords = {Insulin},
title = {Different Effects of Low Selenite and Selenium-Nanoparticle Supplementation on Adipose Tissue Function and Insulin Secretion in Adolescent Male Rats},
doi = {10.3390/nu14173571},
author = {Ojeda, María Luisa and Moreno Fernández, Jorge and Díaz Castro, Javier},
}