@misc{10481/76556,
year = {2022},
month = {7},
url = {http://hdl.handle.net/10481/76556},
abstract = {Cesarean section (CS) disrupts the natural microbiota colonization process in infants,
which might compromise immune system maturation, leading to a higher risk of
infections. We evaluated the effect of the probiotic Limosilactobacillus (L.) fermentum
CECT 5716 on the incidence of gastrointestinal and respiratory infections in the CS infant
subgroups (n = 173) of three randomized clinical trials in which this probiotic strain was
demonstrated to be safe and effective for preventing infections. Therefore, the data for
the CS infants were extracted to obtain the incidence rate ratio (IRR) and 95% CI for
gastrointestinal and respiratory infections for each study and were then combined to
obtain a pooled IRR and 95% CI using the generic inverse variance method. There was
a significant reduction of 73% in the incidence of gastrointestinal infections in CS infants
receiving L. fermentum CECT 5716 compared with those receiving the control formula
[n = 173, IRR: 0.27 (0.13, 0.53), p = 0.0002]. Regarding respiratory infections, although
pooled results showed a reduction of 14% in the probiotic group, the difference was not
statistically significant [n = 173, IRR (95% CI): 0.86 (0.67, 1.11), p = 0.25]. In conclusion,
the administration of L. fermentum CECT 5716 to CS-born infants protects them from
gastrointestinal infections by reducing the risk by up to 73% in this population.},
publisher = {Frontiers},
keywords = {Cesarean section},
keywords = {Probiotics},
keywords = {Infant formula},
keywords = {Gastrointestinal infections},
keywords = {Respiratory infections},
title = {Beneficial Effects of Limosilactobacillus fermentum CECT 5716 Administration to Infants Delivered by Cesarean Section},
doi = {10.3389/fped.2022.906924},
author = {Blanco Rojo, Ruth and Maldonado Lozano, José and López Huertas, Eduardo and Olivares, Mónica},
}