@misc{10481/75982,
year = {2022},
month = {6},
url = {http://hdl.handle.net/10481/75982},
abstract = {Schizophrenia is a heterogeneous and severe psychotic disorder. Epidemiological findings
have suggested that the exposure to infectious agents such as Toxoplasma gondii (T. gondii) is associated
with an increased risk for schizophrenia. On the other hand, there is evidence involving the catechol-
O-methyltransferase (COMT) Val105/158Met polymorphism in the aetiology of schizophrenia since it
alters the dopamine metabolism. A case–control study of 141 patients and 142 controls was conducted
to analyse the polymorphism, the prevalence of anti-T. gondii IgG, and their interaction on the risk
for schizophrenia. IgG were detected by ELISA, and genotyping was performed with TaqMan Real-
Time PCR. Although no association was found between any COMT genotype and schizophrenia,
we found a significant association between T. gondii seropositivity and the disorder ( 2 = 11.71;
p-value < 0.001). Furthermore, the risk for schizophrenia conferred by T. gondii was modified by
the COMT genotype, with those who had been exposed to the infection showing a different risk
compared to that of nonexposed ones depending on the COMT genotype ( 2 for the interaction = 7.28,
p-value = 0.007). This study provides evidence that the COMT genotype modifies the risk for
schizophrenia conferred by T. gondii infection, with it being higher in those individuals with the
Met/Met phenotype, intermediate in heterozygous, and lower in those with the Val/Val phenotype.},
organization = {Junta de Andalucia	P06-CTS-01686},
organization = {Spanish Ministry of Health via the Instituto de Salud Carlos III	FIS PS09/01671	
PI13/01967	
PI18/00467},
organization = {Programa Operativo FEDER	B-CTS-361-UGR18},
publisher = {MDPI},
keywords = {COMT},
keywords = {Toxoplasma gondii},
keywords = {Gene–environment interaction},
keywords = {Schizophrenia},
keywords = {Infectious agents},
keywords = {Case-control study},
title = {Toxoplasma gondii Seropositivity Interacts with Catechol-O-methyltransferase Val105/158Met Variation Increasing the Risk of Schizophrenia},
doi = {10.3390/genes13061088},
author = {Rovira, Paula and Gutiérrez Martínez, Blanca and Sorlozano Puerto, Antonio and Gutiérrez Fernández, José and Molina Rivas, Esther and Rivera Sánchez, Margarita and Martín Laguna, Victoria and Torres González, Francisco and Cervilla Ballesteros, Jorge Antonio},
}