@misc{10481/75178,
year = {2022},
month = {4},
url = {http://hdl.handle.net/10481/75178},
abstract = {alpha-Klotho protein is a powerful predictor of the aging process and lifespan. Although lowered circulating soluble alpha-Klotho levels have been observed in aged non-healthy individuals, no specific reference values across a wide range of ages and sex using an enzyme-linked immunosorbent assay (ELISA) are available for larger cohorts of healthy individuals. The present analytical cross-sectional study was aimed to establish the reference values of soluble alpha-Klotho serum levels in healthy adults by age and sex groups. A total of 346 (59% women) healthy individuals aged from 18 to 85 years were recruited. Subjects were divided by sex and age as: (i) young (18-34.9 years), (ii) middle-aged (35-54.9 years), and (iii) senior (55-85 years) individuals. The soluble alpha-Klotho levels were measured in serum using ELISA. Senior adults were the age-group that presented the lowest soluble alpha-Klotho serum levels (p < 0.01), with age showing a negative association with soluble alpha-Klotho serum levels (p < 0.001). No differences between sexes were observed. Therefore, soluble alpha-Klotho levels were especially decreased-regardless of sex-in our cohort of healthy individuals because of the physiological decline derived from the aging process. We recommend routine assessments of soluble alpha-Klotho levels using ELISA as a simple and cheap detectable marker of aging that improves quality of life in the elderly.},
organization = {Spanish Government	FPU18/03655	
FPU19/01609},
organization = {San Cecilio University Hospital, FIBAO, IBS-Granada, Spain},
publisher = {MDPI},
keywords = {alpha-Klotho protein},
keywords = {Aging},
keywords = {ELISA},
keywords = {References values},
title = {References Values of Soluble alpha-Klotho Serum Levels Using an Enzyme-Linked Immunosorbent Assay in Healthy Adults Aged 18-85 Years},
doi = {10.3390/jcm11092415},
author = {Espuch Oliver, Andrea and Vázquez Lorente, Héctor and Jurado Fasoli, Lucas and Haro Muñoz, Tomás de and Díaz Alberola, Irene and López Vélez, María del Señor and De Haro Romero, Teresa and Castillo Garzón, Manuel and Amaro Gahete, Francisco José},
}