@misc{10481/74760,
year = {2022},
month = {3},
url = {http://hdl.handle.net/10481/74760},
abstract = {Childhood obesity prevention is important to avoid obesity and its comorbidities
into adulthood. Although the energy density of food has been considered a main
obesogenic factor, a focus on food quality rather that the quantity of the different
macronutrients is needed. Therefore, this study investigates the effects of changing the
quality of carbohydrates from rapidly to slowly digestible carbohydrates on metabolic
abnormalities and its impact on obesity in growing rats fed a high-fat diet (HFD).
Growing rats were fed on HFD containing carbohydrates with different digestion
rates: a HFD containing rapid-digesting carbohydrates (OBE group) or slow-digesting
carbohydrates (ISR group), for 4 weeks and the effect on the metabolism and signaling
pathways were analyzed in different tissues. Animals from OBE group presented an
overweight/obese phenotype with a higher body weight gain and greater accumulation
of fat in adipose tissue and liver. This state was associated with an increase of HOMA
index, serum diacylglycerols and triacylglycerides, insulin, leptin, and pro-inflammatory
cytokines. In contrast, the change of carbohydrate profile in the diet to one based
on slow digestible prevented the obesity-related adverse effects. In adipose tissue,
GLUT4 was increased and UCPs and PPARg were decreased in ISR group respect
to OBE group. In liver, GLUT2, FAS, and SRBP1 were lower in ISR group than OBE
group. In muscle, an increase of glycogen, GLUT4, AMPK, and Akt were observed in
comparison to OBE group. In conclusion, this study demonstrates that the replacement
of rapidly digestible carbohydrates for slowly digestible carbohydrates within a highfat
diet promoted a protective effect against the development of obesity and its
associated comorbidities.},
organization = {Abbott
Laboratories S.A.},
publisher = {Frontiers},
keywords = {Obesity},
keywords = {Slow digestive carbohydrates},
keywords = {Metabolism},
keywords = {Lipidomic analysis},
keywords = {Growing rats},
title = {Quality More Than Quantity: The Use of Carbohydrates in High-Fat Diets to Tackle Obesity in Growing Rats},
doi = {10.3389/fnut.2022.809865},
author = {Manzano, Manuel and Girón González, María Dolores and Salto González, Rafael and Vílchez Rienda, José Dámaso and Reche Pérez, Francisco José and Cabrera Cazorla, María Elena and Linares Pérez, Azahara and Plaza Díaz, Julio and Ruiz Ojeda, Francisco Javier and Gil Hernández, Ángel and Rueda, Ricardo and López Pedrosa, José M.},
}