@misc{10481/74675,
year = {2022},
month = {4},
url = {http://hdl.handle.net/10481/74675},
abstract = {Thyroid dysfunction is associated with classic cardiometabolic risk factors in humans. However, this relationship remains
unclear in young euthyroid adults. The present work examines the associations of circulating thyroid hormones (THs) and
thyroid-stimulating hormone (TSH) concentrations with body composition and cardiometabolic risk factors in young euthyroid
adults. A total of 106 sedentary, euthyroid adults (72 women; 22 ± 2 years old) participated in this cross-sectional study. THs
and TSH serum concentrations were determined in fasting conditions (6 h). Body composition (fat mass (FM), lean mass (LM),
and visceral adipose tissue (VAT)) was determined by dual-energy X-ray absorptiometry, anthropometric parameters (weight,
height, and waist circumference) were measured, and neck adipose tissue mass was quantified through computed tomography
(CT) scanning. Cardiometabolic risk factors including fasting glucose and lipid metabolism markers, hepatic phosphatase and
transaminases, and blood pressure were also assessed. Free triiodothyronine (FT3) concentration was positively associated with
body mass index, LM, VAT, and waist circumference (all P ≤ 0.038). FT3 was also associated with glucose, insulin, HOMA-IR,
fatty liver index, and blood pressure (all P < 0.024). All the associations were attenuated when adjusting for sex. In contrast,
we found no associations of TSH or free thyroxine with any body composition parameter or cardiometabolic risk factors. In
conclusion, FT3 is associated with central adiposity and cardiometabolic risk factors including insulin resistance, fatty liver
index, and mean, systolic and diastolic blood pressure in young euthyroid adults. ClinicalTrials.gov identifier: NCT02365129.},
organization = {Universidad de Granada/CBUA},
organization = {Spanish Government	PI13/01393},
organization = {Retos de la Sociedad program	DEP2016-79512-R},
organization = {European Commission},
organization = {Spanish Government	FPU13/04365},
organization = {Fundacion Iberoamericana de Nutricion (FINUT)},
organization = {Redes Tematicas de Investigacion Cooperativa RETIC	Red SAMID RD16/0022},
organization = {AstraZeneca},
organization = {University of Granada Plan Propio de Investigacion 2016-Excellence actions: Unit of Excellence on Exercise and Health (UCEES)},
organization = {Plan Propio de Investigacion 2018-the Programa Contratos-Puente},
organization = {Contratos Perfeccionamiento de Doctores},
organization = {Junta de Andalucia},
organization = {Consejeria de Conocimiento, Investigacion y Universidades (ERDF)	SOMM17/6107/UGR},
organization = {Fundacion Alfonso Martin Escudero},
publisher = {Springer},
keywords = {Thyroid function},
keywords = {Body composition},
keywords = {Cardiometabolic risk factors},
keywords = {Obesity},
keywords = {Euthyroid},
title = {Circulating concentrations of free triiodothyronine are associated with central adiposity and cardiometabolic risk factors in young euthyroid adults},
doi = {10.1007/s13105-022-00881-w},
author = {Merchán Ramírez, Elisa and Sánchez Delgado, Guillermo and Acosta, Francisco M. and Arias Téllez, María José and Muñoz Torres, Manuel Eduardo and García Lario, José Vicente and Llamas Elvira, José Manuel and Ruiz Ruiz, Jonatan},
}