@misc{10481/72898,
year = {2022},
month = {1},
url = {http://hdl.handle.net/10481/72898},
abstract = {Background: The contribution of metabolomic factors to the association of healthy lifestyle with type 2 diabetes risk is unknown. We assessed the association of a composite measure of lifestyle with plasma metabolite profiles and incident type 2 diabetes, and whether relevant metabolites can explain the prospective association between healthy lifestyle and incident type 2 diabetes. Methods: A Healthy Lifestyle Score (HLS) (5-point scale including diet, physical activity, smoking status, alcohol consumption and BMI) was estimated in 1016 Hortega Study participants, who had targeted plasma metabolomic determinations at baseline examination in 2001–2003, and were followed-up to 2015 to ascertain incident type 2 diabetes. Results: The HLS was cross-sectionally associated with 32 (out of 49) plasma metabolites (2.5% false discovery rate). In the subset of 830 participants without prevalent type 2 diabetes, the rate ratio (RR) and rate difference (RD) of incident type 2 diabetes (n cases = 51) per one-point increase in HLS was, respectively, 0.69 (95% CI, 0.51, 0.93), and − 8.23 (95% CI, − 16.34, − 0.13)/10,000 person-years. In single-metabolite models, most of the HLS-related metabolites were prospectively associated with incident type 2 diabetes. In probit Bayesian Kernel Machine Regression, these prospective associations were mostly driven by medium HDL particle concentration and phenylpropionate, followed by small LDL particle concentration, which jointly accounted for ~ 50% of the HLS-related decrease in incident type 2 diabetes. Conclusions: The HLS showed a strong inverse association with incident type 2 diabetes, which was largely explained by plasma metabolites measured years before the clinical diagnosis.},
organization = {CIBER Fisiopatología Obesidad y Nutrición},
organization = {Castilla-Leon Government

GRS/279/A/08},
organization = {European Network of Excellence Ingenious Hypercare

EPSS- 037093},
organization = {State Agency for Research

ACOMP/2013/039, GRUPOS 03/101, PROMETEO/2009/029},
organization = {Strategic Action for Research in Health sciences

INTIMIC-085, PCIN-2017-117},
organization = {Ministerio de Ciencia, Innovación y Universidades

RYC-2018-025069-I},
organization = {European Commission

EPSS-037093},
organization = {Instituto de Salud Carlos III

CB06/03, CB12/03/30016, CD16/00255, CIBER-02-08-2009, PI10/0082, PI11/00726, PI13/01848, PI14/00874, PI16/01402, PI16/1512, PI16/609, PI18/287, PI19/319, PI20/00896},
organization = {Universidad Autónoma de Madrid 820024},
organization = {Agencia Estatal de Investigación

	PID2019-108973RB-C21},
organization = {“La Caixa” Foundation 100010434, LCF/BQ/DR19/11740016, LCF/BQ/IN18/11660001},
publisher = {BioMed Central Ltd},
keywords = {Cohort study},
keywords = {Healthy lifestyle},
keywords = {Metabolomics},
keywords = {Spanish population},
keywords = {Type 2 diabetes},
title = {Healthy lifestyle, metabolomics and incident  type 2 diabetes in a population-based cohort  from Spain},
doi = {10.1186/s12966-021-01219-3},
author = {Monleon Salvado, Daniel and Olmedo Palma, Pablo},
}