@misc{10481/71721,
year = {2021},
month = {8},
url = {http://hdl.handle.net/10481/71721},
abstract = {In search of new Nitric Oxide Synthase (NOS) inhibitor agents, two isosteric series of derivatives with an imidamide scaffold (one of them with a hydroxyl group and the other with a carbonyl one) were synthesized and evaluated on inducible (iNOS) and neuronal (nNOS) isoforms. These compounds have been designed by combining a kynurenamine framework with an amidine moiety in order to improve selectivity for the inducible isoform. In general, the in vitro inhibitory assays exhibited better inhibition values on the iNOS isoform, being the N-(3-(2-amino-5-methoxyphenyl)-3-hydroxypropyl)-4-(trifluoromethyl)benzimidamide 4i the most active inhibitor with the highest iNOS selectivity, without inhibiting eNOS. Docking studies on the two most active compounds suggest a different binding mode on both isozymes, supporting the experimentally observed selectivity towards the inducible isoform. Physicochemical in silico studies suggest that these compounds possess good drug-likeness properties.},
organization = {CSIRC},
organization = {Centro de Supercomputación de la Universidad de Granada},
organization = {Granada University Library},
organization = {European Commission},
organization = {Ministerio de Economía y Competitividad

SAF2017-84894-R},
organization = {Instituto de Salud Carlos III},
organization = {Comisión Interministerial de Ciencia y Tecnología},
publisher = {Elsevier},
keywords = {Drug design},
keywords = {Inhibitors},
keywords = {Imidamides},
keywords = {Nitric Oxide Synthase},
keywords = {Synthesis},
title = {Synthesis, bioevaluation and docking studies of new imidamide derivatives  as nitric oxide synthase inhibitors.},
author = {Arias, Fabio and Franco Moltabán, Francisco and Romero Pérez, Miguel and Carrión Peregrina, María Dora and Camacho Quesada, Encarnación},
}