@misc{10481/70736,
year = {2021},
month = {8},
url = {http://hdl.handle.net/10481/70736},
abstract = {A (core/shell)/shell nanostructure (production performance   50%,mean diameter   330 nm)
was built using maghemite, PLGA, and chitosan. An extensive characterization proved the complete
inclusion of the maghemite nuclei into the PLGA matrix (by nanoprecipitation solvent evaporation)
and the disposition of the chitosan shell onto the nanocomposite (by coacervation). Short-term
stability and the adequate magnetism of the nanocomposites were demonstrated by size and electrokinetic
determinations, and by defining the first magnetization curve and the responsiveness of
the colloid to a permanent magnet, respectively. Safety of the nanoparticles was postulated when
considering the results from blood compatibility studies, and toxicity assays against human colonic
CCD-18 fibroblasts and colon carcinoma T-84 cells. Cisplatin incorporation to the PLGA matrix
generated appropriate loading values ( 15%), and a dual pH- and heat (hyperthermia)-responsive
drug release behaviour ( 4.7-fold faster release at pH 5.0 and 45  C compared to pH 7.4 and 37
 C). The half maximal inhibitory concentration of the cisplatin-loaded nanoparticles against human
lung adenocarcinoma A-549 cells was  1.6-fold less than that of the free chemotherapeutic. Such a
biocompatible and tri-stimuli responsive (maghemite/PLGA)/chitosan nanostructure may found a
promising use for the effective treatment of lung cancer.},
organization = {Instituto de Salud Carlos III
European Commission	PI19/01478},
organization = {Programa Operativo FEDER de Andalucia 2014-2020 (Junta de Andalucia, project I + D + i)	A1-FQM-341-UGR18},
organization = {Programa de Ayudas a Proyectos I + D + i destinadas a Universidades y Entidades Publicas de Investigacion (Junta de Andalucia)	PY20_00346},
publisher = {MDPI},
keywords = {Chitosan},
keywords = {Heat-triggered drug release},
keywords = {Magnetic drug delivery},
keywords = {pH-responsive drug release},
keywords = {PLGA},
keywords = {Triple stimuli-responsive nanoparticle},
title = {A Tri-Stimuli Responsive (Maghemite/PLGA)/Chitosan Nanostructure with Promising Applications in Lung Cancer},
doi = {10.3390/pharmaceutics13081232},
author = {Fernández Álvarez, Fátima and García García, Gracia and Arias Mediano, José Luis},
}