@misc{10481/70583,
year = {2021},
month = {8},
url = {http://hdl.handle.net/10481/70583},
abstract = {Background: While physical activity has consistently been associated with decreased mortality rates, it remains
unknown if there is a single “ideal” combination of time in physical activities of different intensities and sedentary
behavior (SB) associated with the lowest rate. This study examined the associations of combinations of time in
moderate-to-vigorous intensity (MVPA), higher-light intensity (HLPA), lower-light intensity activities (LLPA), and SB
with mortality rates in older women.
Methods: This prospective cohort study included 16,676 older women from throughout the United States enrolled
in the Women’s Health Study. Women wore accelerometers on their hip from 2011 to 2015 and were followed
through 2017 (mean (SD) of 4.3 (1.1) years). Deaths were confirmed with medical records, death certificates, or the
National Death Index. Compositional Cox regression models were used.
Results: The mean (SD) age was 72 (5.7) years at accelerometer wear; 503 women died. Compared to the least
active women (mean, 3 min/day MVPA, 27 min/day HLPA, 162 min/day LLPA, and 701 min/day SB): compositional
models showed an inverse L-shaped dose-response association of MVPA replacing other behaviors with mortality
rates mortality rates (P = .02); SB relative to LLPA, HLPA, and MVPA was directly associated with mortality rates in a
curvilinear dose-response manner (P < .001); replacing 10 min of SB for MVPA (HR (95% CI) = .86 (.73–.98)) or for
HLPA (HR (95% CI.94 (.88–1.00)) associated with 14 and 6% lower mortality rates, respectively; a 47% risk reduction
(HR [95% CI] = .53 [.42–.64]) was observed among women meeting physical activity guidelines (mean, 36 min/day
MVPA, 79 min/day HLPA, 227 min/day LLPA and 549 min/day SB); and similar mortality rate reductions of 43% (HR
(95% CI) = .57 (.41–.73)) were observed with increases in HLPA and LLPA without increasing MVPA, e.g., reallocating
SB to 90 min/day of HLPA plus 120 min/day of LLPA.
Conclusions: There was no “ideal” combination of physical activities of different intensities and SB associated with
the lowest mortality rates. Of particular relevance to older women, replacing SB with light intensity activity was
associated with lower mortality rates, and “mixing and matching” times in different intensities yielded equivalent
mortality risk reductions.},
organization = {United States Department of Health & Human Services
National Institutes of Health (NIH) - USA	CA154647	
CA047988	
CA182913	
HL043851	
HL080467	
HL099355},
organization = {Intramural Research Program at the National Institute on Aging},
organization = {Spanish Ministry of Education, Culture and Sport	FPU15/02645},
organization = {Spanish Government	FJC2018-037925-I},
organization = {University of Granada, Plan Propio de Investigacion 2016, Excellence actions: Units of Excellence},
organization = {Scientific Excellence Unit on Exercise and Health (UCEES)},
organization = {United States Department of Health & Human Services},
organization = {National Institutes of Health (NIH) - USA},
publisher = {BMC},
title = {Revisiting the association of sedentary behavior and physical activity with all-cause mortality using a compositional approach: the Women's Health Study},
doi = {10.1186/s12966-021-01173-0},
author = {Hidalgo Migueles, Jairo and Cadenas Sánchez, Cristina and Ortega Porcel, Francisco Bartolomé},
}