@misc{10481/70520,
year = {2021},
month = {7},
url = {http://hdl.handle.net/10481/70520},
abstract = {BACKGROUND: Iron deficiency and iron overload can affect the normal functioning of the innate and adaptive immune
responses. Fermented milk products may enhance immune functions, but little is known about the effect of fermented milks
on modulation of the immune response during iron deficiency anemia and recovery with normal or high dietary iron intake.
Eighty male Wistar rats were randomly assigned to a control group fed a standard diet or to an anemic group fed a diet deficit
in iron. Control and anemic groups were fed for 30 days with diets based on a fermented goat's or cow's milk product, with normal
iron content or iron overload.
RESULTS: In general, during anemia recovery lectin and alternative complement pathway activity and lactoferrin decreased,
because it improves iron homeostasis, which is critically important in immune system functions. Fermented goat's milk diet
enhanced immune function during iron deficiency recovery, suppressed oxidant-induced eotaxin and fractalkine expression
due to the concurrent reduction of free radical production and pro-inflammatory cytokines, and decreased monocyte chemoattractant
protein-1 and monocyte migration and adhesion. The increase in interferon-γ can confer immunological colonization
of gut microbiota and downregulate inflammation.
CONCLUSION: Fermented goat's milk consumption enhances immune function, modifying complement pathway activity and
decreasing pro-inflammatory cytokines as well as lactoferrin concentration, due to the improvement of iron homeostasis, which
is critically important in the normal function of the immune system.},
organization = {Regional Government of Andalusia, Excellence Research Project	P11-AGR-7648},
organization = {Spanish Ministry of Education, Culture and Sport (MECD)},
organization = {University of Granada},
organization = {University of Granada / CBUA},
publisher = {García-Burgos, M... [et al.] (2021), Fermented goat's milk modulates immune response during iron deficiency anemia recovery. J Sci Food Agric. [https://doi.org/10.1002/jsfa.11448]},
keywords = {Fermented goat milk},
keywords = {Iron deficiency anemia},
keywords = {Iron overload},
keywords = {Cellular immunity},
keywords = {Immune function biomarkers},
keywords = {Complement pathways},
title = {Fermented goat's milk modulates immune response during iron deficiency anemia recovery},
doi = {10.1002/jsfa.11448},
author = {García Burgos, María and Moreno Fernández, Jorge and Díaz Castro, Javier and Muñoz Alférez, María José and López Aliaga, María Inmaculada},
}