@misc{10481/69929,
year = {2021},
month = {6},
url = {http://hdl.handle.net/10481/69929},
abstract = {Bacteria have evolved sophisticated signaling mechanisms to coordinate interactions with
organisms of other domains, such as plants, animals and human hosts. Several important signal
molecules have been identified that are synthesized by members of different domains and that play
important roles in inter-domain communication. In this article, we review recent data supporting
that histamine is a signal molecule that may play an important role in inter-domain and inter-species
communication. Histamine is a key signal molecule in humans, with multiple functions, such as
being a neurotransmitter or modulator of immune responses. More recent studies have shown that
bacteria have evolved different mechanisms to sense histamine or histamine metabolites. Histamine
sensing in the human pathogen Pseudomonas aeruginosa was found to trigger chemoattraction to
histamine and to regulate the expression of many virulence-related genes. Further studies have
shown that many bacteria are able to synthesize and secrete histamine. The release of histamine by
bacteria in the human gut was found to modulate the host immune responses and, at higher doses,
to result in host pathologies. The elucidation of the role of histamine as an inter-domain signaling
molecule is an emerging field of research and future investigation is required to assess its potential
general nature.},
organization = {European Commission},
organization = {Fondo Social Europeo through CSIC	PIE-202040I003},
organization = {Spanish Ministry for Science, Innovation and Universities	PID2019-103972GA-I00},
organization = {Junta de Andalucia	P18-FR-1621},
organization = {Spanish Ministry of Economy and Competitiveness	BIO2016-76779-P	
BIO2016-74875-P},
organization = {Spanish Ministry of Science and Innovation, Promotion of Talent and its Employability-Ramon y Cajal RDi Programme	RYC2019-026481-I},
publisher = {MDPI},
keywords = {Histamine},
keywords = {Signal molecule},
keywords = {Sensing},
keywords = {Pseudomonas aeruginosa},
keywords = {Histamine receptors},
keywords = {Chemotaxis},
keywords = {Gut microbiome},
title = {Histamine: A Bacterial Signal Molecule},
doi = {10.3390/ijms22126312},
author = {Krell, Tino and Gavira Gallardo, José Antonio and Velando, Félix and Fernández Rodríguez, Matilde and Roca Hernández, Amalia de la Arrixac and Monteagudo Cascales, Elizabet and Matilla, Miguel A.},
}