@misc{10481/69548,
year = {2021},
url = {http://hdl.handle.net/10481/69548},
abstract = {The objective of the present study was to investigate the effects of chronic lead exposure
on the mineral properties of alveolar bone. For this purpose, female Wistar rats (n = 8) were exposed
to 1000 ppm lead acetate in drinking water for 90 days, while the control group (n = 5) was treated
with sodium acetate. The alveolar bone structure and chemical composition of the dissected man‐
dibles were examined using micro‐computed tomography (micro‐CT), scanning electron micros‐
copy (SEM), inductively coupled plasma optical emission spectrometry (ICP‐OES), attenuated total
reflection Fourier transform infrared spectroscopy (ATR‐FTIR), and X‐ray diffraction (XRD) tech‐
niques to determine possible alterations in alveolar bone due to lead exposure. In addition, changes
in bone mechanical properties were analysed using a three‐point bending test. Exposure to lead
induced notable changes in bone mineralization and properties, specifically a reduction of the tra‐
becular thickness and bone mineral density. Furthermore, there was a reduction in carbonate con‐
tent and an increase in bone mineral crystallinity. These changes in bone mineralization could be
explained by an alteration in bone turnover due to lead exposure. Three‐point bending showed a
trend of decreased displacement at failure in the mandibles of lead‐exposed rats, which could com‐
promise the mechanical stability and normal development of the dentition.},
organization = {MICINN‐CGL2011‐25906 (Spain)},
organization = {UBACYT‐
20020150100006BA (Argentina)},
publisher = {MDPI},
keywords = {Lead intoxication},
keywords = {Alveolar process},
keywords = {Bone mineralization},
keywords = {Trabecular morphology},
keywords = {Apatite crystallinity},
keywords = {Mechanical properties},
title = {Chronic Lead Exposure Alters Mineral Properties    in Alveolar Bone},
doi = {10.3390/min11060642},
author = {Álvarez Lloret, Pedro and Benavides Reyes, Cristina and Lee, Ching Ming and Martínez Narváez-Cabeza de Vaca, María del Pilar and Conti, María Inés and Rodríguez Navarro, Alejandro and González López, Santiago and Perez Huerta, Alberto and Terrizzi, Antonela Romina},
}