@misc{10481/69148,
year = {2021},
month = {4},
url = {http://hdl.handle.net/10481/69148},
abstract = {It remains unclear whether caffeinated beverages could have deleterious renal effects in elderly population with underlying comorbid conditions. We investigated the associations between coffee, tea, or caffeine intake and 1-year changes in glomerular filtration rate (eGFR) in a large Spanish cohort of overweight/obese elderly with metabolic syndrome (MetS). This prospective analysis includes 5851 overweight/obese adults (55-75 years) with MetS from the PREDIMED-Plus study. We assessed coffee, tea, and caffeine consumption from a validated food-frequency questionnaire and creatinine-based eGFR using the Chronic Kidney Disease Epidemiology Collaboration equation. Multivariate-adjusted regression models were applied to test associations between baseline coffee, tea, or caffeine intake and 1-year eGFR changes. Caffeinated coffee (> 2 cups/day) and tea (at least 1 cup/day) drinkers had 0.88 and 0.93 mL/min/1.73 m(2) greater eGFR decrease respectively, compared to those with less than 1 cup/day of coffee consumption or non-tea drinkers. Furthermore, caffeinated coffee consumption of > 2 cups/day was associated with 1.19-fold increased risk of rapid eGFR decline > 3 mL/min/1.73 m(2) (95% CI 1.01-1.41). Similarly, individuals in the highest (median, 51.2 mg/day) tertile of caffeine intake had a 0.87 mL/min/1.73 m(2) greater eGFR decrease. Decaffeinated coffee was not associated with eGFR changes. In conclusion, higher consumption of caffeinated coffee, tea, and caffeine was associated with a greater 1-year eGFR decline in overweight/obese adults with MetS.},
organization = {CIBER Fisiopatologia de la Obesidad y Nutricion (CIBEROBN)},
organization = {Instituto de Salud Carlos III (ISCIII), through the Fondo de Investigacion para la Salud (FIS) - European Regional Development Fund 

PI13/00673
PI13/00492
PI13/00272
PI13/01123
PI13/00462
PI13/00233
PI13/02184
PI13/00728
PI13/01090
PI13/01056
PI14/01722
PI14/00636
PI14/00618
PI14/00696
PI14/01206
PI14/01919
PI14/00853
PI14/01374
PI14/00972
PI14/00728
PI14/01471
PI16/00473},
organization = {European Research Council (ERC)

European Commission

340918},
organization = {La Caixa Foundation

2013ACUP00194},
organization = {Junta de Andalucia

PI0458/2013
PS0358/2016
PI0137/2018},
organization = {Generalitat Valenciana

European Commission

PROMETEO/2017/017},
organization = {European Commission

CB06/03},
organization = {International Nut & Dried Fruit Council - FESNAD (Long-term effects of an energy-restricted Mediterranean diet on mortality and cardiovascular disease 2014 -2015) 

201302},
organization = {SEMERGEN grant},
organization = {AstraZeneca},
organization = {Balearic Islands Gov.; FEDER funds 

35/2011},
organization = {(ISCIII) grant 

JR17/00022},
organization = {Boosting young talent call grant program for the development of IISPV research projects 2019-2021 

2019/IISPV/03},
organization = {Societat Catalana d'Endocrinologia i Nutricio (SCEN) Clinical-Research Grant 2019},
organization = {Collaborative Nutrition and/or Obesity Project for Young Researchers 2019 - CIBEROBN},
organization = {Spanish Ministry of Education, Culture and Sports 

FPU17/01925},
organization = {ICREA},
organization = {the Instituto de Salud Carlos III (ISCIII), through the Fondo de Investigacion para la Salud (FIS) - European Regional Development Fund 

PI17/01441
PI17/00508
PI17/01732
PI17/00926
PI19/00957
PI19/00386
PI19/00309
PI19/01032
PI19/00576
PI19/00017
PI19/01226
PI19/00781
PI19/01560
PI19/01332
PI20/01802
PI20/00138
PI20/01532
PI20/00456
PI20/00339
PI20/00557
PI20/00886
PI20/01158},
organization = {'Instituto de Salud Carlos III (ISCIII), through the Fondo de Investigacion para la Salud (FIS) - European Regional Development Fund' 

PI16/00662
PI16/01873
PI16/01094
PI16/00501
PI16/00533
PI16/00381
PI16/00366
PI16/01522
PI16/01120
PI17/00764
PI17/01183
PI17/00855
PI17/01347
PI17/00525
PI17/01827
PI17/00532
PI17/00215},
publisher = {Nature},
title = {Consumption of caffeinated beverages and kidney function decline in an elderly Mediterranean population with metabolic syndrome},
doi = {10.1038/s41598-021-88028-7},
author = {Díaz López, Andrés and Bueno Cavanillas, Aurora},
}