@misc{10481/68436,
year = {2021},
url = {http://hdl.handle.net/10481/68436},
abstract = {Fatigue is a cardinal symptom in fibromyalgia. Fatigue is assumed to be the result of genetic
susceptibility and environmental factors. We aimed at examining the role of genetic susceptibility for
fatigue in southern Spanish women with fibromyalgia, by looking at single nucleotide polymorphisms
in 34 fibromyalgia candidate-genes, at the interactions between genes, and at the gene-physical
activity interactions. We extracted DNA from saliva of 276 fibromyalgia women to analyze genepolymorphisms. Accelerometers registered physical activity and sedentary behavior. Fatigue was
assessed with the Multidimensional Fatigue Inventory. Based on the Bonferroni’s and False Discovery
Rate values, we found that the genotype of the rs4453709 polymorphism (sodium channel protein type
9 subunit alpha, SCN9A, gene) was related to reduced motivation (AT carriers showed the highest
reduced motivation) and reduced activity (AA carriers showed the lowest reduced activity). Carriers
of the heterozygous genotype of the rs1801133 (methylene tetrahydrofolate reductase, MTHFR,
gene) or rs4597545 (SCN9A gene) polymorphisms who were physically active reported lower scores
on fatigue compared to their inactive counterparts. Highly sedentary carriers of the homozygous
genotype of the rs7607967 polymorphism (AA/GG genotype; SCN9A gene) presented more reduced
activity (a dimension of fatigue) than those with lower levels of sedentary behavior. Collectively findings from the present study suggest that the contribution of genetics and gene-physical activity
interaction to fatigue in fibromyalgia is modest.},
organization = {Spanish Ministry of Economy and Competitiveness
[I + D + i DEP2010-15639, I + D + i DEP2013-40908-R to M.D.-F.; BES-2014-067612 to F.E.-L.]},
organization = {Spanish Ministry of Education [FPU13/03410 to D.S.-T.; FPU 15/00002 to B.G.-C.]},
organization = {Consejería de
Turismo, Comercio y Deporte, Junta de Andalucía [CTCD-201000019242-TRA to M.D.-F.]},
organization = {University of Granada, Plan Propio de Investigación 2016, Excellence actions: Units of Excellence;
Unit of Excellence on Exercise and Health (UCEES)},
publisher = {MDPI},
keywords = {Accelerometry},
keywords = {Chronic pain},
keywords = {Epidemiology},
keywords = {Gene polymorphism},
keywords = {Rehabilitation},
keywords = {Treatment},
title = {Fatigue in Women with Fibromyalgia: A Gene-Physical Activity Interaction Study},
doi = {10.3390/jcm10091902},
author = {Estévez López, Fernando and Aparicio García-Molina, Virginia and Acosta Manzano, Pedro and Gavilán Carrera, Blanca and Delgado Fernández, Manuel and Ruiz Ruiz, Jonatan and Álvarez Cubero, María Jesús},
}