@misc{10481/67965,
year = {2021},
url = {http://hdl.handle.net/10481/67965},
abstract = {Novel artificial tissues with potential usefulness in local-based therapies have been generated by tissue engineering
using magnetic-responsive nanoparticles (MNPs). In this study, we performed a comprehensive in vivo
characterization of bioengineered magnetic fibrin-agarose tissue-like biomaterials. First, in vitro analyses were
performed and the cytocompatibility of MNPs was demonstrated. Then, bioartificial tissues were generated and
subcutaneously implanted in Wistar rats and their biodistribution, biocompatibility and functionality were
analysed at the morphological, histological, haematological and biochemical levels as compared to injected
MNPs. Magnetic Resonance Image (MRI), histology and magnetometry confirmed the presence of MNPs restricted
to the grafting area after 12 weeks. Histologically, we found a local initial inflammatory response that
decreased with time. Structural, ultrastructural, haematological and biochemical analyses of vital organs showed
absence of damage or failure. This study demonstrated that the novel magnetic tissue-like biomaterials with
improved biomechanical properties fulfil the biosafety and biocompatibility requirements for future clinical use
and support the use of these biomaterials as an alternative delivery route for magnetic nanoparticles.},
organization = {• Grants FIS-PI17/0391 and FIS-PI17/0393 from Instituto de Salud
Carlos III - ISCIII (Plan Nacional de Investigación Científica,
Desarrollo e Innovación Tecnológica I + D + i from the Spanish
Ministerio de Ciencia e Innovación), co-financed by ERDF-FEDER,
European Union. • Award number AC17/00013 (NanoGSkin) by ISCIII thorough AES
2017 and within the EuroNanoMed framework. • Grant FIS2017-85954-R funded by Ministerio de Economía,
Industria y Competitividad, MINECO, and Agencia Estatal de
Investigación, AEI, Spain, cofunded by Fondo Europeo de Desarrollo
Regional, FEDER, European Union. • Grants CS PI-0257-2017 and CSyF PE-0395-2019 from Consejería de
Salud y Familias, Junta de Andalucía, Spain. • Grant n° Res SECYT 411/18 from SECYT (Secretary of Science and
Technology of National University of Córdoba, Argentina) • Project Future Investments UCA JEDI, No. ANR-15-IDEX-01, project
“RheoGel” by the French “Agence Nationale de la Recherche”.},
title = {In vivo time-course biocompatibility assessment of biomagnetic nanoparticles-based biomaterials for tissue engineering applications},
doi = {https://doi.org/10.1016/j.msec.2020.111476},
author = {Campos, Fernando and Bonhome Espinosa, Ana Belén and Carmona Martos, Ramón and Duran, Juan DG and Kuzhir, Pavel and Alaminos Mingorance, Miguel and López López, Modesto Torcuato and Rodriguez, Ismael A and Carriel Araya, Víctor},
}