@misc{10481/67554,
year = {2021},
month = {2},
url = {http://hdl.handle.net/10481/67554},
abstract = {Non-alcoholic fatty liver disease (NAFLD) is an increasing cause of chronic liver illness
associated with obesity and metabolic disorders, such as hypertension, dyslipidemia, or type 2 diabetes
mellitus. A more severe type of NAFLD, non-alcoholic steatohepatitis (NASH), is considered
an ongoing global health threat and dramatically increases the risks of cirrhosis, liver failure, and
hepatocellular carcinoma. Several reports have demonstrated that liver steatosis is associated with the
elevation of certain clinical and biochemical markers but with low predictive potential. In addition,
current imaging methods are inaccurate and inadequate for quantification of liver steatosis and do not
distinguish clearly between the microvesicular and the macrovesicular types. On the other hand, an
unhealthy status usually presents an altered gut microbiota, associated with the loss of its functions.
Indeed, NAFLD pathophysiology has been linked to lower microbial diversity and a weakened
intestinal barrier, exposing the host to bacterial components and stimulating pathways of immune
defense and inflammation via toll-like receptor signaling. Moreover, this activation of inflammation
in hepatocytes induces progression from simple steatosis to NASH. In the present review, we aim to:
(a) summarize studies on both human and animals addressed to determine the impact of alterations
in gut microbiota in NASH; (b) evaluate the potential role of such alterations as biomarkers for
prognosis and diagnosis of this disorder; and (c) discuss the involvement of microbiota in the current
treatment for NAFLD/NASH (i.e., bariatric surgery, physical exercise and lifestyle, diet, probiotics
and prebiotics, and fecal microbiota transplantation).},
organization = {National Agency for Research and Development (ANID) BECAS Chile 

72180543},
organization = {"Fundación Ramon Areces", Madrid, Spain},
organization = {'Fundación Alfonso Martin Escudero' (Spain)},
publisher = {Mdpi},
keywords = {Non-alcoholic steatohepatitis},
keywords = {Intestinal permeability},
keywords = {Microbiota},
keywords = {Probiotics},
keywords = {Physical exercise},
keywords = {Fecal microbiota transplantation},
title = {Insights into the Impact of Microbiota in the Treatment of NAFLD/NASH and Its Potential as a Biomarker for Prognosis and Diagnosis},
doi = {10.3390/biomedicines9020145},
author = {Plaza Díaz, Julio and Álvarez Mercado, Ana Isabel},
}