@misc{10481/66457,
year = {2020},
month = {11},
url = {http://hdl.handle.net/10481/66457},
abstract = {A reproducible and efficient interfacial polymer disposition method has been used to
formulatemagnetite/poly("-caprolactone) (core/shell) nanoparticles (average size   125 nm, production
performance   90%). To demonstrate that the iron oxide nuclei were satisfactorily embedded within
the polymeric solid matrix, a complete analysis of these nanocomposites by, e.g., electron microscopy
visualizations, energy dispersive X-ray spectroscopy, Fourier-transform infrared spectroscopy,
electrophoresis, and contact angle goniometry was conducted. The magnetic responsive behaviour
of these nanoparticles was quantitatively characterized by the hysteresis cycle and qualitatively
investigated by visualization of the colloid under exposure to a 0.4 T magnet. Gemcitabine entrapment
into the polymeric shell reported adequate drug loading values ( 11%), and a biphasic and
pH-responsive drug release profile ( four-fold faster Gemcitabine release at pH 5.0 compared
to pH 7.4). Cytotoxicity studies in MCF-7 human breast cancer cells proved that the half maximal
inhibitory concentration of Gem-loaded nanocomposites was  two-fold less than that of the free drug.
Therefore, these core/shell nanoparticles could have great possibilities as a magnetically targeted
Gemcitabine delivery system for breast cancer treatment.},
organization = {FEDER, Plan Nacional de Investigación Científica, Desarrollo e Innovación Tecnológica (I+D+i), Instituto de Salud Carlos III (FIS, Spain) 	
PI19/01478},
publisher = {Mdpi},
keywords = {Breast cancer},
keywords = {Core/shell},
keywords = {Drug loading},
keywords = {Gemcitabine},
keywords = {Magnetic drug delivery},
keywords = {Magnetite},
keywords = {pH-responsive drug release},
keywords = {Poly("-caprolactone)},
keywords = {Polymer-coated nanoparticle},
title = {Gemcitabine-Loaded Magnetically Responsive Poly("-caprolactone) Nanoparticles against Breast Cancer},
doi = {10.3390/polym12122790},
author = {García García, Gracia and Fernández Álvarez, Fátima and Cabeza Montilla, Laura and Delgado Mora, Ángel Vicente and Melguizo Alonso, Consolación and Prados Salazar, José Carlos and Arias Mediano, José Luis},
}