@misc{10481/64310,
year = {2020},
month = {7},
url = {http://hdl.handle.net/10481/64310},
abstract = {Summary: Exosomes are extracellular vesicles released by the vast majority of cell types both in vivo and ex vivo, upon the fusion of multivesicular bodies (MVBs) with the cellular plasma membrane. Two main functions have been attributed to exosomes: their capacity to transport proteins, lipids and nucleic acids between cells and organs, as well as their potential to act as natural intercellular communicators in normal biological processes and in pathologies. From a clinical perspective, the majority of applications use exosomes as biomarkers of disease. A new approach uses exosomes as biologically active carriers to provide a platform for the enhanced delivery of cargo in vivo. One of the major limitations in developing exosome-based therapies is the difficulty of producing sufficient amounts of safe and efficient exosomes. The identification of potential proteins involved in exosome biogenesis is expected to directly cause a deliberate increase in exosome production. In this review, we summarize the current state of knowledge regarding exosomes, with particular emphasis on their structural features, biosynthesis pathways, production techniques and potential clinical applications.},
organization = {Spanish ISCIII Health Research Fund 	
PI12/01097
PI15/02015
PI18/00337
PIE16-00045
DTS19/00145
PI18/00330},
organization = {European Union (EU)
	
PI12/01097
PI15/02015
PI18/00337
PIE16-00045
DTS19/00145
PI18/00330},
organization = {Spanish Ministry of Science, Innovation and Universities (MICIU) through FEDER research grant 	
RTI2018-101309-B-C2},
organization = {CECEyU Council of the Junta de Andalucia FEDER/European Cohesion Fund (FSE) 	
2016000073391-TRA
2016000073332-TRA
PI-57069
PAIDI-Bio326
PI-0014-2016},
organization = {CSyF Council of the Junta de Andalucia FEDER/European Cohesion Fund (FSE) 	
2016000073391-TRA
2016000073332-TRA
PI-57069
PAIDI-Bio326
PI-0014-2016},
organization = {Nicolas Monardes Regional Ministry of Health contract 	
0006/2018},
organization = {Research Excellence PhD Fellowship from the National Center for Scientific and Technical Research (CNRST) 	
2UAE2020},
organization = {Spanish Government
	
FPU16/05467},
organization = {SMSI through a GJ fellowship 	
PEJ-2018-001760-A},
publisher = {MDPI},
keywords = {Immunotherapy},
keywords = {Exosomes},
keywords = {CARs},
keywords = {Gene editing},
keywords = {Cancer},
keywords = {Liquid biopsies},
title = {Exosome: A New Player in Translational Nanomedicine},
doi = {10.3390/jcm9082380},
author = {Aheget, Houssam and Galindo Moreno, Pablo Antonio and Marchal Corrales, Juan Antonio},
}