@misc{10481/64053,
year = {2012},
month = {1},
url = {http://hdl.handle.net/10481/64053},
abstract = {Tetrodotoxin (TTX) is a potent neurotoxin that blocks voltage-gated sodium channels (VGSCs). VGSCs play a critical role in neuronal function under both physiological and pathological conditions. TTX has been extensively used to functionally characterize VGSCs, which can be classified as TTX-sensitive or TTX-resistant channels according to their sensitivity to this toxin. Alterations in the expression and/or function of some specific TTX-sensitive VGSCs have been implicated in a number of chronic pain conditions. The administration of TTX at doses below those that interfere with the generation and conduction of action potentials in normal (non-injured) nerves has been used in humans and experimental animals under different pain conditions. These data indicate a role for TTX as a potential therapeutic agent for pain. This review focuses on the preclinical and clinical evidence supporting a potential analgesic role for TTX. In addition, the contribution of specific TTX-sensitive VGSCs to pain is reviewed.},
organization = {National Health and Medical Research Council of Australia

German Research Foundation (DFG)},
organization = {Spanish Government},
organization = {University of Granada 	
GREIB (CEB-005)},
organization = {Junta de Andalucía

CTS 109},
publisher = {Mdpi},
keywords = {Tetrodotoxin},
keywords = {TTX},
keywords = {TTX-sensitive voltage-gated sodium channels},
keywords = {Pain},
keywords = {Neuropathic pain},
title = {Tetrodotoxin (TTX) as a Therapeutic Agent for Pain},
doi = {10.3390/md10020281},
author = {Nieto, Francisco Rafael and Cobos del Moral, Enrique José and Tejada, Miguel Ángel and Sánchez Fernández, Cristina and González Cano, Rafael and Cendán, Cruz Miguel},
}