@misc{10481/63522,
year = {2020},
month = {7},
url = {http://hdl.handle.net/10481/63522},
abstract = {Recent studies investigated the association of cardiorespiratory ftness with white matter
microstructure in children, yet little work has explored to what extent other components of physical
ftness (i.e., muscular or motor ftness) are associated with white matter microstructure. Indeed,
this association has not been previously explored in children with overweight/obesity who present a
diferent white matter development. Therefore, we aimed to examine associations between physical
ftness components and white matter microstructure in children with overweight/obesity. In total, 104
(10.04 ± 1.15 years old; 43 girls) children were included in this cross-sectional study. Physical ftness
was assessed using the ALPHA-ftness test battery. Fractional anisotropy (FA) and mean difusivity
were derived from difusion tensor imaging (DTI). No association was found between physical ftness
and global DTI metrics (all P> 0.082). Within individual tracts, all associations became non-signifcant
when analyses were adjusted for multiple comparisons. Using the voxel-wise approach, we identifed
a small cluster in the left lateral frontal lobe where children with greater upper-body muscular ftness
showed higher FA (PFWE-corrected = 0.042). Although our results cannot conclude physical ftness is related
to white matter microstructure in children with overweight/obesity; those fndings indicate that the
association of muscular ftness with white matter microstructure might be more focal on frontal areas
of the brain, as opposed to global diferences.},
organization = {Spanish Ministry of Economy and Competitiveness 	
DEP2013-47540
DEP2016-79512-R
DEP2017-91544-EXP
RTI2018-095284-J-100},
organization = {European Union (EU)},
organization = {European Commission Joint Research Centre

667302},
organization = {Alicia Koplowitz Foundation},
organization = {University of Granada, Research and Knowledge Transfer Fund (PPIT) 2016},
organization = {Excellence Actions Programme: Units of Excellence},
organization = {Scientific Unit of Excellence on Exercise and Health (UCEES)},
organization = {Andalusian Regional Government},
organization = {Regional Ministry of Economy, Knowledge, Entreprises and University},
organization = {European Union (EU)

SOMM17/6107/UGR},
organization = {SAMID III network, RETICS - PN I+D+I 2017-2021 (Spain)},
organization = {Spanish Ministry of Education, Culture and Sport 	
FPU14/06837
FPU 16/02760},
organization = {Government of Andalusian, Integrated Territorial Initiative 2014-2020 for the province of Cadiz 	
PI-0002-2017},
organization = {Spanish Ministry of Science, Innovation and Universities 	
FJCI-2017-33396},
publisher = {Nature Research},
title = {Physical ftness and white matter microstructure in children with overweight or obesity: the ActiveBrains project},
doi = {10.1038/s41598-020-67996-2},
author = {Rodríguez Ayllon, María and Esteban Cornejo, Irene and Verdejo Román, Juan and Mora-González, José and Cadenas Sánchez, Cristina and Plaza Florido, Abel Adrián and Molina García, Pablo and Catena Martínez, Andrés},
}