@misc{10481/63406,
year = {2020},
month = {7},
url = {http://hdl.handle.net/10481/63406},
abstract = {The development of nanotechnology-based solutions for cancer at a preclinical level
advances at an astounding pace. So far, clinical translation of these new developments has not been
able to keep the pace due to a range of different reasons. One of them is the mismatch between
in vitro and in vivo results coming from the expected difference in complexity. To overcome this
problem, extensive characterisation using advanced in vitro models can lead to stronger preliminary
data to face in vivo tests. Here, a comprehensive in vitro validation of a combinatorial therapy
nanoformulation against solid tumours is presented. The information extracted from the different
in vitro models highlights the importance of advanced 3D models to fully understand the potential
of this type of complex drugs.},
organization = {"Local specific treatment of triple-negative-breast-cancer through externally triggered target-less drug carriers" project - FCT 	
031142},
organization = {ERDF through NORTE2020},
organization = {Portuguese Foundation for Science and Technology

UTAP-EXPL/NTec/0038/2017},
organization = {2014-2020 INTERREG Cooperation Programme Spain-Portugal (POCTEP) 	
0624_2IQBIONEURO_6_E},
publisher = {MDPI},
keywords = {Magnetic nanocomposites},
keywords = {Magnetic Hyperthermia},
keywords = {Combinatorial therapy},
keywords = {3D in vitro models},
keywords = {Drug Delivery},
title = {Evaluation of Novel Doxorubicin-Loaded Magnetic Wax Nanocomposite Vehicles as Cancer Combinatorial Therapy Agents},
doi = {doi:10.3390/pharmaceutics12070637},
author = {Jiménez López, Julia and García Hevia, Lorena and Melguizo Alonso, Consolación and Prados Salazar, José Carlos},
}