@misc{10481/62975,
year = {2020},
month = {5},
url = {http://hdl.handle.net/10481/62975},
abstract = {The limited success and side effects of the current chemotherapeutic strategies against
colorectal cancer (CRC), the third most common cancer worldwide, demand an assay with new drugs.
The prominent antitumor activities displayed by the bengamides (Ben), a family of natural products
isolated from marine sponges of the Jaspidae family, were explored and investigated as a new option
to improve CRC treatment. To this end, two potent bengamide analogues, Ben I (5) and Ben V (10),
were selected for this study, for which they were synthesized according to a new synthetic strategy
recently developed in our laboratories. Their antitumor effects were analyzed in human and mouse
colon cell lines, using cell cycle analysis and antiproliferative assays. In addition, the toxicity of the
selected analogues was tested in human blood cells. These biological studies revealed that Ben I
and V produced a significant decrease in CRC cell proliferation and induced a significant cell cycle
alteration with a greater antiproliferative effect on tumor cell lines than normal cells. Interestingly,
no toxicity effects were detected in blood cells for both compounds. All these biological results render
the bengamide analogues Ben I and Ben V as promising antitumoral agents for the treatment of CRC.},
organization = {MINECO 	
BIO2014-56092-R
RTI2018-098296-BI00
CTQ2016-76311},
organization = {European Union (EU)

BIO2014-56092-R
RTI2018-098296-BI00
CTQ2016-76311
P12-CTS-1507},
organization = {Andalusian Government 	
P12-CTS-1507
BIO-267
CTS-107},
organization = {Instituto de Salud Carlos III

European Union (EU)

PI19/01478},
organization = {Junta de Andalucia

PI-0102-2017},
publisher = {MDPI},
keywords = {Bengamides},
keywords = {Analogues},
keywords = {Synthesis},
keywords = {Antitumor agents},
keywords = {Colorectal cancer},
title = {Bengamide Analogues Show A Potent Antitumor Activity against Colon Cancer Cells: A Preliminary Study},
doi = {10.3390/md18050240},
author = {García Pinel, Beatriz and Cabeza, Laura and Ortiz, Raúl and Prados Salazar, José Carlos and Melguizo Alonso, Consolación},
}