@misc{10481/62737,
year = {2020},
month = {4},
url = {http://hdl.handle.net/10481/62737},
abstract = {Phytochemicals from Lippia citriodora leaves were extracted by applying an innovative
technology based on the use of microwaves, which represents an alternative method to extract
bioactive substances. The obtained extract was incorporated into phospholipid vesicles in order to
promote the antioxidant effect of the bioactive molecules present in L. citriodora extract. The extract was
analyzed by High Performance Liquid Chromatography coupled to Time-Of-Flight mass spectrometer
by electrospray (HPLC-ESI-TOF-MS) and different phytochemicals were detected and quantified.
The whole extract was incorporated in liposomes, glycerosomes (liposomes modified with glycerol)
and propylene glycol-containing vesicles (PG-PEVs). Moreover, a biopolymer obtained from fish
by-product, that is Thunnus albacares skin, was added to improve the bioactivity of the formulations.
The in vitro biocompatibility and the antioxidant efficacy of the extract in solution or loaded in the
vesicles were tested in primary mouse embryonic fibroblasts (3T3). The results showed the superior
bioactivity of the vesicle formulations over the aqueous solution of the extract, which points to
an interesting strategy for the treatment of skin disorders.},
organization = {This APC was partially funded by RTI2018-096724-B-C22 (Ministry of science, Innovation
and Universities).},
publisher = {MDPI},
keywords = {Lippia citriodora},
keywords = {Green extraction},
keywords = {Phospholipid vesicles},
keywords = {Antioxidant},
keywords = {Thunnus albacares},
keywords = {Skin delivery},
title = {Incorporation of Lippia citriodora Microwave Extract into Total-Green Biogelatin-Phospholipid Vesicles to Improve Its Antioxidant Activity},
doi = {10.3390/nano10040765},
author = {Leyva Jiménez, Francisco Javier and Lozano Sánchez, Jesús and Arráez Román, David and Segura Carretero, Antonio},
}