@misc{10481/62489,
year = {2020},
month = {4},
url = {http://hdl.handle.net/10481/62489},
abstract = {Adipose tissue programming could be developed in very preterm infants with extrauterine
growth restriction (EUGR), with an adverse impact on long-term metabolic status, as was studied in
intrauterine growth restriction patterns. The aim of this cohort study was to evaluate the difference in
levels of plasma adipokines in children with a history of EUGR. A total of 211 school age prepubertal
children were examined: 38 with a history of prematurity and EUGR (EUGR), 50 with a history of
prematurity with adequate growth (PREM), and 123 healthy children born at term. Anthropometric
parameters, blood pressure, metabolic markers and adipokines (adiponectin, resistin, leptin) were
measured. Children with a history of EUGR showed lower values of adiponectin (µg/mL) compared
with the other two groups: (EUGR: 10.6 vs. PREM: 17.7, p < 0.001; vs. CONTROL: 25.7, p = 0.004) and
higher levels of resistin (ng/mL) (EUGR: 19.2 vs. PREM: 16.3, p =0.007; vs. CONTROL: 7.1, p < 0.001.
The PREM group showed the highest values of leptin (ng/mL), compared with the others: PREM: 4.9
vs. EUGR: 2.1, p = 0.048; vs. CONTROL: 3.2, p = 0.029). In conclusion, EUGR in premature children
could lead to a distinctive adipokines profile, likely associated with an early programming of the
adipose tissue, and likely to increase the risk of adverse health outcomes later in life.},
organization = {This study was supported by the Plan Nacional de Investigación Científica, Desarrollo e Innovación
Tecnológica (Iþ DþI), Instituto de Salud Carlos III-Fondo de Investigación Sanitaria Project No. PI13/01245 from
the Spanish Ministry of Health and Consumer Affairs and co-financed by the Consejería de Innovación y Ciencia,
Junta de Andalucía, PI-0480-2012, Spain. The funding bodies did not partake in the design, collection, analyses or
interpretation of the data or in writing the manuscript.},
publisher = {MDPI},
keywords = {Metabolic syndrome},
keywords = {Programming},
keywords = {Adiponectin},
keywords = {Leptin},
keywords = {Resistin},
keywords = {Prematurity},
keywords = {Extrauterine growth restriction},
title = {Plasma Adipokines Profile in Prepubertal Children with a History of Prematurity or Extrauterine Growth Restriction},
doi = {doi:10.3390/nu12041201},
author = {Ordóñez Díaz, María Dolores and Aguilera García, Concepción María},
}