@misc{10481/59787,
year = {2019},
url = {http://hdl.handle.net/10481/59787},
abstract = {Decellularized vascular scaffolds are promising materials for vessel replacements. However, despite the natural origin of
decellularized vessels, issues such as biomechanical incompatibility, immunogenicity risks, and the hazards of thrombus formation
still need to be addressed. In this study, we assess the mechanical properties of two groups of porcine carotid blood vessels: (i)
native arteries and (ii) decellularized arteries.The biomechanical properties of both groups (n = 10, sample size of each group) are
determined by conducting uniaxial and circumferential tensile tests by using an ad hoc and lab-made device comprising a peristaltic
pump that controls the load applied to the sample. This load is regularly incremented (8 grams per cycle with a pause of 20 seconds
after each step) while keeping the vessels continuously hydrated. The strain is measured by an image cross-correlation technique
applied on a high-resolution video. The mechanical testing analyses of the arteries revealed significant differences in burst pressure
between the native (1345.08±96.58 mbar) and decellularized (1067.79±112.13 mbar) groups.Moreover, decellularized samples show
a significantly lower maximum load at failure (15.78±0.79 N) in comparison with native vessels (19.42±0.80 N). Finally, the average
ultimate circumferential tensile also changes between native (3.71±0.37 MPa) and decellularized (2.93±0.18 MPa) groups. This
technique is able to measure the strain in the regime of large displacements and enables high-resolution image of the local strains,
thus providing a valuable tool for characterizing several biomechanical parameters of the vessels also applicable to other soft tissue
presenting hyperelastic behaviours.},
organization = {This research was supported by the Ministry of Education
[DPI2014-51870-R, DPI2017-85359-R, UNGR15-CE-
3664, and PI16/00339], Junta de Andalucía [PIN-0030-
2017, PIN-0379, CTS-6568, and PI-0107-2017 Projects], and
University of Granada [PP2017-PIP2019]. Ministerio de
Economía y Competitividad is also acknowledged for funding
the project [TEC2014-57394-P] and MNat Scientific Unit
of Excellence (UCE.PP2017.03).},
publisher = {Hindawi},
title = {High-Resolution Strain Measurement for Biomechanical Parameters Assessment in Native and Decellularized Porcine Vessels},
doi = {10.1155/2019/2402606},
author = {Melchor, Juan and Soto, Juan M. and López Ruiz, Elena and Suárez Medina, Francisco Javier and Jiménez, Gema and Antich Acedo, Cristina and Perán, Macarena and Marchal Corrales, Juan Antonio and Rus Carlborg, Guillermo},
}