@misc{10481/59631,
year = {2019},
url = {http://hdl.handle.net/10481/59631},
abstract = {Anti-inflammatory properties of artichoke pectin and modified fractions (arabinose- and galactose-free)
used at two doses (40 and 80 mg kg−1) in mice with colitis induced by dextran sulfate sodium have been
investigated. Expression of pro-inflammatory markers TNF-α and ICAM-I decreased in groups of mice
treated with original and arabinose-free artichoke pectin while IL-1β and IL-6 liberation was reduced only
in mice groups treated with original artichoke pectin. A decrease in iNOS and TLR-4 expression was
observed for most treatments. Intestinal barrier gene expression was also determined. MUC-1 and
Occludin increased in groups treated with original artichoke pectin while MUC-3 expression also
increased in arabinose-free pectin treatment. Galactose elimination led to a loss of pectin bioactivity.
Characteristic expression profiles were established for each treatment through artificial neural networks
showing high accuracy rates (≥90%). These results highlight the potential amelioration of inflammatory
bowel disease on mice model colitis through artichoke pectin administration.},
organization = {This work has been funded by MICINN of Spain, Projects
AGL2014-53445-R and AGL2017-84614-C2-1-R. Carlos Sabater
thanks his FPU Predoc contract from Spanish MECD (FPU14/
03619).},
publisher = {Royal Society of Chemistry},
title = {Intestinal anti-inflammatory effects of artichoke pectin and modified pectin fractions in the dextran sulfate sodium model of mice colitis. Artificial neural network modelling of inflammatory markers},
doi = {10.1039/c9fo02221j},
author = {Sabater, Carlos and Molina Tijeras, José Alberto and Vezza, Teresa and Corzo, Nieves and Montilla, Antonia and Utrilla Navarro, Pilar},
}