@misc{10481/59414,
year = {2018},
month = {12},
url = {http://hdl.handle.net/10481/59414},
abstract = {Zinc is a key trace element in normal prostate cell metabolism, and is decreased in neoplastic
cells. However, the association between dietary zinc and prostate cancer (PC) in epidemiologic studies
is a conflicting one. Our aim was to explore this association in an MCC-Spain case-control study,
considering tumor aggressiveness and extension, as well as genetic susceptibility to PC. 733 incident
cases and 1228 population-based controls were included for this study. Dietary zinc was assessed
using a food frequency questionnaire, and genetic susceptibility was assessed with a single nucleotide
polymorphisms (SNP)-based polygenic risk score (PRS). The association between zinc intake and PC was evaluated with mixed logistic and multinomial regression models. They showed an increased
risk of PC in those with higher intake of zinc (Odds Ratio (OR) tertile 3vs1: 1.39; 95% Confidence
interval (CI):1.00–1.95). This association was mainly observed in low grade PC (Gleason = 6 RRR
tertile 3vs1: 1.76; 95% CI:1.18–2.63) as well as in localized tumors (cT1-cT2a RRR tertile 3vs1: 1.40; 95%
CI:1.00–1.95) and among those with higher PRS (OR tertile 3vs1: 1.50; 95% CI:0.89–2.53). In conclusion,
a higher dietary zinc intake could increase the risk of low grade and localized tumors. Men with
higher genetic susceptibility might also have a higher risk of PC associated with this nutrient intake.},
organization = {The study was supported by the “Acción Transversal del Cáncer”, approved on the Spanish Ministry
Council on the 11 October 2007, by the Consortium for Biomedical Research in Epidemiology and Public Health
(CIBERESP), by the Instituto de Salud Carlos III grants, co-funded by FEDER funds -a way to build Europe-
PI08/1770, PI09/0773, PI12/00715, PI09/1903,PI09/2078; PI09/1662; PI11/01403; PI12/00150; PI12/00488;
PI15/00914; PI17CIII_00034;by the Fundación Marqués de Valdecilla grant API 10/09, by the Consejería de
Salud of the Junta de Andalucía grant 2009-S0143, by the Conselleria de Sanitat of the Generalitat Valenciana grant
AP061/10, by the Regional Government of the Basque Country, by the Fundación Caja de Ahorros de Asturias,
by the University of Oviedo and by the Spanish Ministry of Economy and Competitiveness Juan de la Cierva de
Incorporación grant IJCI-2014-20900.},
publisher = {MDPI},
keywords = {Dietary zinc},
keywords = {Prostate cancer},
keywords = {Diet},
keywords = {Genetic susceptibility},
title = {Dietary Zinc and Risk of Prostate Cancer in Spain: MCC-Spain Study},
doi = {10.3390/nu11010018},
author = {Gutiérrez González, Enrique and Salcedo Bellido, Inmaculada},
}