@misc{10481/58431,
year = {2019},
month = {12},
url = {http://hdl.handle.net/10481/58431},
abstract = {An antibody panel is needed to definitively differentiate between adenocarcinoma (AC)
and squamous cell carcinoma (SCC) in order to meet more stringent requirements for the histologic
classification of lung cancers. Staining of desmosomal plaque-related proteins may be useful in the
diagnosis of lung SCC. The specificity for SCC of membrane staining for PKP1, KRT15, and DSG3 was 97.4%, 94.6%,
and 100%, respectively, and it was 100% when the markers were used together and in combination
with the conventional markers (AUCs of 0.7619 for Panel 1 SCC, 0.7375 for Panel 2 SCC, 0.8552 for
Panel 1 AC, and 0.8088 for Panel 2 AC). In a stepwise multivariate logistic regression model, the combination
of CK5/6, p63, and PKP1 in membrane was the optimal panel to differentiate between SCC
and AC, with a percentage correct classification of 96.2% overall (94.6% of ACs and 97.6% of SCCs).
PKP1 and DSG3 are related to the prognosis. PKP1, KRT15, and DSG3 are highly specific for SCC, but they were more useful to differentiate
between SCC and AC when used together and in combination with conventional markers.
PKP1 and DSG3 expressions may have prognostic value.},
organization = {MEFV was supported by PAIDI programme, Group BIO309, Junta de
Andalucía.},
publisher = {Taylor & Francis},
keywords = {Adenocarcinoma},
keywords = {Desmosomal plaque proteins},
keywords = {Nonsmall- cell lung cancer},
keywords = {Squamous cell carcinoma},
title = {The value of desmosomal plaque-related markers to distinguish squamous cell carcinoma and adenocarcinoma of the lung},
doi = {10.1080/03009734.2019.1692101},
author = {Galindo, Inmaculada and Gómez Morales, Mercedes and Díaz Cano, Inés and Andrades Delgado, Álvaro and Caba Molina, Mercedes and Miranda León, María Teresa and Medina Vico, Pedro Pablo and Martín Padrón, Joel and Farez Vidal, María Esther},
}