@misc{10481/58009, year = {2019}, month = {7}, url = {http://hdl.handle.net/10481/58009}, abstract = {Levels of dialkylphosphate (DAP) metabolites were measured in hair and urine of children that lived close to intensively farmed areas of Almeria (Southeast Spain). The levels were used as proxies for exposure of these children to organophosphate pesticides (OPs). Determinants of exposure to DAPs were also examined. Urine and hair samples were collected from 222 children aged 3–11 years and information on lifestyle and dietary habits was collected from questionnaires administered to mothers. Urinary DAPs were analyzed by ultra-high performance liquid-chromatography coupled to triple-quadrupole tandem mass-spectrometry (UHPLC-QqQ-MS/MS) and hair DAPs by gas-chromatography coupled to mass spectrometry (GC–MS). Detection rates ranged from 21.8% for diethylphosphate (DEP) and diethylthiophosphate (DETP) to 35.9% for dimethylphosphate (DMP) in urine; and from 42.3% for DETP to 92.8% for DMP in hair. Diethyldithiophosphate (DEDTP) was detected in 0.5% of urine samples (one child), and in 26.6% of children's hair samples. A lack of correlation was observed for individual DAP metabolites and ΣDAPs between urine and hair samples, except for DEDTP. Urinary DAP levels of our child population were lower than those reported for children from other countries, including NHANES 1999–2000 data.}, organization = {This study was partially funded by the Ministry of Economy, Innovation, Science and Employment, Government of Andalucia (reference number P08-CTS-04313, FEDER funds).}, publisher = {Elsevier BV}, keywords = {Pesticides}, keywords = {DAPs}, keywords = {Hair}, keywords = {Urine}, keywords = {Children}, keywords = {Biomonitoring}, title = {Biomonitoring of common organophosphate metabolites in hair and urine of children from an agricultural community}, doi = {10.1016/j.envint.2019.104997}, author = {Hernández Jérez, Antonio Francisco and Lozano Paniagua, David and González Alzaga, Beatriz and Kavvalakis, Matthaios and Tzatzarakis, Manolis and López Flores, Inmaculada and Aguilar Garduño, Clemente and Caparrós González, Rafael Arcángel and Tsatsakis, Aristidis and Lacasaña Navarro, Marina}, }