@misc{10481/57912,
year = {2019},
month = {9},
url = {http://hdl.handle.net/10481/57912},
abstract = {Objectives: The aim of this research was to determine the osseointegration of two
presentations of biphasic calcium phosphate (BCP) biomaterial—one untreated and another submitted
to biofunctionalization with a TGF- 1 inhibitor peptide, P144, on dental alveolus. The biofunctionalization of the biomaterial’s
granules maintains a stable membranous bone formation throughout the experiment timeline,
benefitting from the constant presence of vascular structures in the alveolar space, in a more active
manner that in the control samples. Better results in the experimental groups were proven both
by quantitative and qualitative analysis. Synthetic bone graft biofunctionalization
results in slightly better quantitative parameters of the implant’s osseointegration. The qualitative
histological and ultramicroscopic analysis shows that biofunctionalization may shorten the healing
period of dental biomaterials.},
organization = {The present study was supported entirely by the Research Cathedra Klockner-University of Granada.},
publisher = {MDPI},
keywords = {Osseointegration},
keywords = {Biofunctionalization},
keywords = {Histomorphometrical analysis},
keywords = {Scanning electron microscopy},
keywords = {Synthetic bone graft},
keywords = {TGFbeta- 1},
title = {Biofunctionalization with a TGFβ-1 Inhibitor Peptide in the Osseointegration of Synthetic Bone Grafts: An In Vivo Study in Beagle Dogs},
doi = {10.3390/ma12193168},
author = {Cirera, Andrea and Manzanares, María Cristina and Sevilla, Pablo and Ortiz Hernández, Mónica and Galindo Moreno, Pablo Antonio and Gil, Javier},
}