@misc{10481/55575,
year = {2018},
month = {3},
url = {http://hdl.handle.net/10481/55575},
abstract = {In this work a combined, multifunctional platform, which was devised for the simultaneous
application of magnetic hyperthermia and the delivery of the antitumor drug gemcitabine, is
described and tested in vitro. The system consists of magnetite particles embedded in a polymer
envelope, designed to make them biocompatible, thanks to the presence of poly (ethylene glycol) in
the polymer shell. The commercial particles, after thorough cleaning, are provided with carboxyl
terminal groups, so that at physiological pH they present negative surface charge. This was proved by
electrophoresis, and makes it possible to electrostatically adsorb gemcitabine hydrochloride, which is
the active drug of the resulting nanostructure. Both electrophoresis and infrared spectroscopy are
used to confirm the adsorption of the drug. The gemcitabine-loaded particles are tested regarding
their ability to release it while heating the surroundings by magnetic hyperthermia, in principle
their chances as antitumor agents. The release, with first-order kinetics, is found to be faster when
carried out in a thermostated bath at 43 ºC than at 37 ºC, as expected. But, the main result of this
investigation is that while the particles retain their hyperthermia response, with reasonably high
heating power, they release the drug faster and with zeroth-order kinetics when they are maintained
at 43 ºC under the action of the alternating magnetic field used for hyperthermia.},
organization = {This research work is supported by MINECO Ramón y Cajal programme (RYC-2014-16901);
Junta de Andalucía (PE2012-FQM694) and Feder Funds UE.},
publisher = {MDPI},
keywords = {Biocompatible polymer},
keywords = {Drug delivery},
keywords = {Gemcitabine},
keywords = {Magnetic Hyperthermia},
keywords = {Magnetic nanoparticles},
title = {Hyperthermia-Triggered Gemcitabine Release from Polymer-Coated Magnetite Nanoparticles},
author = {Iglesias Salto, Guillermo Ramón and Reyes Ortega, Felisa and Checa Fernandez, B. L. and Delgado Mora, Ángel Vicente},
}