@misc{10481/28268,
year = {2000},
url = {http://hdl.handle.net/10481/28268},
abstract = {Se estudio el efecto de clorgilina y deprenil sobre la liberación y el metabolismo de 3H-noradrenalina (3H-NA) en el
ganglio superior (GCS) y en la membrana nictitante (MN) de gato. Nuestros resultados muestran que en el GCS,
clorgilina y deprenil redujeron del mismo modo la formación de 3,4-dihidroxi-fenilglicol (DOPEG) mientras que en
la MN la disminución del DOPEG fue mayor con clorgilina que con deprenil. En el GCS la monoaminooxidasa
(MAO) A y B cataliza la deaminación de NA a 3H-DOPEG, a 3H-3,4-acido-dihidroximandílico (3H-DOMA) o a los
metabolitos 3H—O-metilados deaminados (3H-OMDA). En la MN la MAO-A presináptica cataliza la deaminación
de NA principalmente a 3H-DOPEG, la MAO-B postsináptica a 3H-NMN y; la MAO-A y B a 3H-DOMA y 3H-OMDA.},
abstract = {The effect of clorgyline and deprenyl on the release and metabolism of 3H-noradrenaline (3H-NA) was studied in the
superior cervical ganglion (SCG) and nictitating membrane (NM) of the cat. Our results show that in SCG, clorgyline
and deprenyl reduced to the same degree the formation of 3,4-dihydroxy-phenylglycol (DOPEG) whereas in NM the
decrease of DOPEG was more pronounced in presence of clorgyline than of deprenyl. In SCG the deamination of NA
to either 3H-DOPEG, 3H-3,4-dihydroxymandelic acid (3H-DOMA) or 3H-0-methylated deaminated metabolites (3H-OMDA)
is catalized by monoamineoxydase (MAO) A and B. In NM the deamination of NA to 3H-DOPEG is mainly catalized
by MAO-A presynaptic, 3H-NMN by MAO-B postsynaptic, and 3H-DOMA and 3H-OMDA by MAO-A and B.},
publisher = {Universidad de Granada, Facultad de Farmacia},
keywords = {Clorgilina},
keywords = {Clorgyline},
keywords = {Deprenil},
keywords = {Deprenyl},
keywords = {MAO-A},
keywords = {MAO-B},
title = {Effect of mao-A and mao-B inhibitors in ganglia and nerve endings},
author = {Filinger, E.},
}