@misc{10481/28170,
year = {2004},
url = {http://hdl.handle.net/10481/28170},
abstract = {Se investiga la actividad antibacteriana de soluciones de las quinolonas ácido nalidíxico, ciprofloxacino y levofloxacino
irradiadas mediante luz UVA. La fotólisis de las quinolonas produce una disminución de la actividad antibacteriana
en cepas de E.coli y de S.aureus, evidenciándose un aumento de la concentración mínima inhibitoria de un 50%
frente a las cepas ensayadas, en relación a las quinolonas no irradiadas. Se postula un mecanismo fotolítico radicalario
con la consecuente fotodegradación de la porción γ-piridona-β-carboxílica responsable de la actividad antibacteriana.},
abstract = {The antibacterial activity of UVA-irradiated solutions of nalidixic acid, ciprofloxacin and levofloxacin was investigated.
Photolysis of quinolones produced a decrease in antibacterial activity in strains of E. coli and S. aureus, becoming
manifest through an increase of 50% in the minimum inhibitory concentration of the drug as compared to nonirradiated
quinolones. In this study, it is suggested that a radical-mediated photolytic mechanism exists, leading to the
photodegradation of the γ-piridone-β-carboxylic group, which is the mediator that is responsible for the drugs antibacterial
activity.},
publisher = {Universidad de Granada, Facultad de Farmacia},
keywords = {Quinolonas},
keywords = {Quinolones},
keywords = {Fotolisis},
keywords = {Photolysis},
keywords = {CMI},
keywords = {MIC},
keywords = {Fotodegradación},
keywords = {Photodegradation},
title = {Pérdida de la actividad antibacteriana de quinolonas por efecto de la radiación UVA},
author = {Fernández, E. and Sánchez, G. and Navarrete, E. and Alcázar, F. del},
}