@misc{10481/27352,
year = {2010},
url = {http://hdl.handle.net/10481/27352},
abstract = {In the present study, effect of ethanolic extract of bark of Tectona grandis Linn. (TG) was evaluated
using alloxan induced diabetes and associated renal complication. The diabetes was induced by
administration of alloxan to the rats at the dose of 140 mg/kg, i.p. TG was administered to diabetic
animals for six weeks and various biochemical parameters in blood and urine (plasma glucose, serum
albumin, total protein, and creatinine, urine total protein, urine albumin), tissue parameters
(cholesterol and triglyceride in kidney homogenate) and % change in body weight were evaluated
along with histopathological study. In present study diabetic animals treated with TG showed
significant reduction in the elevated level of plasma glucose (p<0.01) when compared with diabetic
control. While considering renal parameters, diabetic animals treated with TG showed significant
decrease in serum creatinine (p<0.05), urine albumin and urine total protein levels (p<0.01) and
significant increase in serum albumin, total protein and % change in body weight (p<0.01) when
compared with diabetic control. Diabetic control showed significant increase in total cholesterol and
triglyceride accumulation in kidney, while diabetic animals treated with TG showed significant
decrease in levels of total cholesterol (p<0.01) and triglyceride (p<0.05) in the kidney when compared
with diabetic control. Diabetic control showed significant mark of glomerulosclerosis and
hyalinization which occurs because of severe diabetic condition (diabetic nephropathy). Diabetic
groups treated with TG showed absence of the sclerotic lesions produced by diabetic condition. Hence,
the results obtained in the present study indicate that Tectona grandis has the potential to treat diabetes
mellitus and prevent the associated renal damage.},
publisher = {Universidad de Granada, Facultad de Farmacia},
keywords = {Alloxan},
keywords = {Creatinine},
keywords = {Glucose},
keywords = {Nephropathy},
keywords = {Tectona grandis},
title = {Antidiabetic and nephroprotective effect of tectona grandis linn. In alloxan induced diabetes},
author = {Ghaisas, Mahesh M. and Navghare, V.V. and Takawale, A.R. and Zope, V.S. and Phanse, M.A.},
}