@misc{10481/26297,
year = {2012},
url = {http://hdl.handle.net/10481/26297},
abstract = {Aim: The present investigation concerns the development of controlled release matrix tablet of Diltiazem HCl.
Methods: Matrix tablet of Diltiazem HCl was formulated by using HPMC and Guar gum as a polymeric matrix forming materials in various concentrations (%w/w) to study their ability to retard the release. The tablets were prepared by wet granulation method and evaluated for physical properties, content uniformity, swelling index, stability and in-vitro drug release.
Results: Swelling was increased as the concentration and viscosity of HPMC increases. Tablets formulated using guar gum and HPMC alone were gave initial burst effect followed by controlled release for 8 hr. It was evident from the study that the formulationsF7,F8 &F9 have optimum swelling index and in vitro drug release up to 44% in 8hrs. The stability studies of optimized batch showed that there was no change in hardness, swelling index and in-vitro release up to 12 weeks.
Conclusions: The batches F7, F8 and F9 possessed the high potential to release the drug gradually for more than 8 hours. The zero-order release kinetic indicates concentration independent drug release ensuring that the formulated tablet showed promising result to be a sustained release formulation.},
abstract = {Objetivos: En el presente trabajo se describe el desarrollo de comprimidos matriciales de clorhidrato de diltiazem.
Métodos: Se obtienen comprimidos matriciales mediante el uso de goma guar y HPMC. Se estudian distintas formulaciones en las que se cambia la composición de estos materiales matriciales como controladores de la cesión. Los comprimidos se prepararon por el método de granulación húmeda y se evaluaron uniformidad de contenido, índice de hinchamiento, estabilidad y velocidad de liberación.
Resultados: La capacidad de hinchamiento aumenta con el porcentaje utilizado de HPMC. Las formulaciones F7, F8 y F9 son las que muestran mejores características de liberación. Los estudios de estabilidad de la formulación seleccionada demuestran una buena resistencia a la rotura, capacidad de hinchamiento y control de la velocidad de disolución durante el estudio de estabilidad.
Conclusiones: Las formulaciones F7, F8 y F9 tienen unas buenas propiedades de control de liberación del fármaco durante al menos 8 horas. La cinética de liberación se pueden ajustar a un orden cero.},
publisher = {Universidad de Granada, Facultad de Farmacia},
keywords = {HPMC},
keywords = {Guar gum},
keywords = {Goma guar},
keywords = {Diltiazem HCl},
keywords = {Diltiazem HCl},
keywords = {Controlled release},
keywords = {Liberación controlada},
keywords = {Matrix tablets},
keywords = {Comprimidos matriciales},
title = {Formulation and evaluation of controlled release matrix tablet of diltiazem HCl by using HPMC and guar gum as polymeric matrix material},
author = {Shah, UH. and Patel, B.K. and Patel, M.R.},
}