TY  - GEN 
AU  - Romero, Maria Luisa
AU  - García Seisdedos, Héctor
AU  - Ibarra Molero, Beatriz
PY  - 2022
UR  - https://hdl.handle.net/10481/97691
AB  - The stabilization of natural proteins is a long-standing desired goal in protein engineering. Optimizing the hydrophobicity of the protein core often results in extensive stability enhancements. However, the presence of totally or partially buried...
LA  - eng
PB  - Wiley
KW  - genotype–phenotype mapping
KW  - partial least squares reconstruction
KW  - protein design
TI  - Active site center redesign increases protein stability preserving catalysis in thioredoxin
DO  - 10.1002/pro.4417
ER  -