TY - GEN AU - Pacheco García, Juan Luis AU - Cano Muñoz, Mario AU - Pey Rodríguez, Ángel Luis PY - 2022 UR - https://hdl.handle.net/10481/77757 AB - Phosphoglycerate kinase has been a model for the stability, folding cooperativity and catalysis of a two-domain protein. The human isoform 1 (hPGK1) is associated with cancer development and rare genetic diseases that affect several of its features.... LA - eng PB - Nature TI - Loss of stability and unfolding cooperativity in hPGK1 upon gradual structural perturbation of its N‑terminal domain hydrophobic core DO - 10.1038/s41598-022-22088-1 ER -